Obesity, metabolic syndrome, diabetes and smoking

Ferreira, Isabel, van de laar, Roel J. and Stehouwer, Coen D. A. (2014). Obesity, metabolic syndrome, diabetes and smoking. In Michel E. Safar, Michael O'Rourke and Edward D. Flohlich (Ed.), Blood pressure and arterial wall mechanics in cardiovascular diseases (pp. 409-422) London, United Kingdom: Springer. doi:10.1007/978-1-4471-5198-2_33

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Author Ferreira, Isabel
van de laar, Roel J.
Stehouwer, Coen D. A.
Title of chapter Obesity, metabolic syndrome, diabetes and smoking
Title of book Blood pressure and arterial wall mechanics in cardiovascular diseases
Place of Publication London, United Kingdom
Publisher Springer
Publication Year 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/978-1-4471-5198-2_33
Open Access Status
ISBN 9781447151975
Editor Michel E. Safar
Michael O'Rourke
Edward D. Flohlich
Volume number 9781447151982
Chapter number 33
Start page 409
End page 422
Total pages 14
Total chapters 45
Collection year 2015
Language eng
Abstract/Summary It is becoming increasingly clear that arterial stiffness may be determined not only by age(ing) and blood pressure, but also by exposure to other cardiovascular risk factors. This chapter reviews the evidence provided by studies adopting an aetiological model of analyses of determinants of arterial stiffness, mainly derived, if available, from prospective designs. Specifically, the following risk factors are examined: the critical axis (central) obesity – metabolic syndrome – (type 2) diabetes, and also smoking. There is convincing evidence, reinforced by recent aetiological prospective studies, that these risk factors, all of which may be preventable, increase arterial stiffness. This may explain, at least in part, the increased cardiovascular disease risk observed in these conditions. However, the molecular basis of greater arterial stiffness associated with these risk factors remains to be fully elucidated. In addition, the prognostic significance of arterial stiffness indices in individuals with these risk factors, and the extent to which intervention on these risk factors improves cardiovascular outcome through beneficial impact on arterial stiffness, is still unclear. Given the high and/or increasing prevalence of these risk factors, these issues constitute an important research agenda.
Keyword Arterial stiffness
Central obesity
Metabolic Syndrome
Risk factors
Life course
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
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Created: Fri, 15 May 2015, 10:37:03 EST by Isabel Ferreira on behalf of School of Public Health