Absorption of sunscreens across human skin: an evaluation of commercial products for children and adults

Jiang, R, Roberts, MS, Collins, DM and Benson, HAE (1999) Absorption of sunscreens across human skin: an evaluation of commercial products for children and adults. British Journal of Clinical Pharmacology, 48 4: 635-637.

Author Jiang, R
Roberts, MS
Collins, DM
Benson, HAE
Title Absorption of sunscreens across human skin: an evaluation of commercial products for children and adults
Journal name British Journal of Clinical Pharmacology   Check publisher's open access policy
Publication date 1999
Sub-type Article
Volume number 48
Issue number 4
ISSN 0306-5251
Start page 635
End page 637
Total pages 3
Language eng
Abstract Aims Topical sunscreens are routinely applied to the skin by a large percentage of the population. This study assessed the extent of absorption of a number of common chemical sunscreen agents into and through human skin following application of commercially available products. Methods Sunscreen products were applied to excised human epidermis in Franz diffusion cells with the amount penetrating into and across the epidermis assessed by h.p.l.c. for 8 h following application. Results All sunscreen agents investigated penetrated into the skin (0.25 g m(-2) or 14% of applied dose), but only benzophenone-3 passed through the skin in significant amounts (0.08 g m(-2) or 10% of the applied dose). With one exception, suncreen agents in corresponding products marketed for adults and children had similar skin penetration profiles. Conclusions Whilst limited absorption across the skin was observed for the majority of the sunscreens tested, benzophenone-3 demonstrated sufficiently high penetration to warrant further investigation of its continued application.
Keyword Pharmacology & Pharmacy
Skin Penetration
Sunscreen
Topical Application
Agents
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article
Collection: School of Medicine Publications
 
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Created: Mon, 13 Aug 2007, 11:23:55 EST