Association of a glucocorticoid receptor gene marker with human essential hypertension.

Guerrini, V., Rutherford, S., Nyholt, D. R. and Griffiths, L. R. (1999). Association of a glucocorticoid receptor gene marker with human essential hypertension.. In 49th Annual Meeting of American Society of Human Genetics, October 19- 23, 1999, (A237-A237), San Francisco, CA.

Document type: Conference Item
Collection: School of Veterinary Science Publications

Author(s) Guerrini, V.
Rutherford, S.
Nyholt, D. R.
Griffiths, L. R.
Title Association of a glucocorticoid receptor gene marker with human essential hypertension.
Conference name 49th Annual Meeting of American Society of Human Genetics
Conference Item Type Published Abstract
Proceedings title American Journal of Human Genetics
Conference location San Francisco, CA
Conference dates October 19- 23, 1999
Place Published Cambridge, MA
Publisher Cell Press
ISSN 0002-9297; 1537-6605
Publication date 1999
Volume number 65
Issue number Supplement
Start page A237
End page A237
Total pages 1
Language eng
Subject 11 Medical and Health Sciences
Abstract/Summary Recently, a bi-allelic polymorphism in the glucocorticoid receptor gene (GRL) has been shown to be associated with individuals at high risk of developing hypertension and accumulation of abdominal visceral fat, a known risk factor for cardiovascular disease. The evaluate the role of GRL in essential hypertension and obesity, case-control studies were conducted using 88 hypertensive, 123 normotensive, 150 lean and 94 obese subjects. Genotypes for a highly polymorphic microsatellite marker (D5S207) located within 200 kb of the glucocorticoid receptor gene, were determined by PCR. Allele frequencies between hypertensive and normotensive groups were significantly (P = 0.0005) different whereas no significant differences were observed between lean and obese populations. In conclusion, the results suggest that the glucocorticoid receptor gene or perhaps another gene located in close proximity and in linkage disequilibrium with D5S207, is involved in hypertension development
Keyword(s) Genetics & Heredity
 
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