Dendritic cells: the driving force behind autoimmunity in rheumatoid arthritis?

Pettit, Allison R. and Thomas, Ranjeny (1999) Dendritic cells: the driving force behind autoimmunity in rheumatoid arthritis?. Immunology and Cell Biology, 77 5: 420-427. doi:10.1046/j.1440-1711.1999.00855.x


Author Pettit, Allison R.
Thomas, Ranjeny
Title Dendritic cells: the driving force behind autoimmunity in rheumatoid arthritis?
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 0818-9641
1440-1711
Publication date 1999
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1046/j.1440-1711.1999.00855.x
Volume 77
Issue 5
Start page 420
End page 427
Total pages 8
Place of publication London, United Kingdom
Publisher Nature
Language eng
Abstract Dendritic cells (DC) are likely to play a significant role in immune-mediated diseases such as autoimmunity and allergy. To date there are few treatments capable of inducing permanent remission in rheumatoid arthritis (RA) and elucidation of the role of DC may provide specific strategies for disease intervention. Dendritic cells have proven to be powerful tools for immunotherapy and investigations are under way to determine their clinical efficacy in transplantation and viral and tumour immunotherapy. The present review will focus on the current view of DC and their role in autoimmunity, in particular RA. Two possible roles for DC in the pathogenesis of RA will be proposed, based on recent advances in the field.
Keyword Autoimmunity
Dendritic cells
Rheumatoid arthritis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Diamantina Institute - Open Access Collection
UQ Diamantina Institute Publications
 
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Created: Mon, 13 Aug 2007, 11:22:55 EST