Hydration and endocrine responses to intravenous fluid and oral glycerol

van Rosendal, S. P., Strobel, N. A., Osborne, M. A., Fassett, R. G. and Coombes, J. S. (2015) Hydration and endocrine responses to intravenous fluid and oral glycerol. Scandinavian Journal of Medicine and Science in Sports, 25 S1: 112-125. doi:10.1111/sms.12367

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Author van Rosendal, S. P.
Strobel, N. A.
Osborne, M. A.
Fassett, R. G.
Coombes, J. S.
Title Hydration and endocrine responses to intravenous fluid and oral glycerol
Journal name Scandinavian Journal of Medicine and Science in Sports   Check publisher's open access policy
ISSN 1600-0838
Publication date 2015-06-01
Sub-type Article (original research)
DOI 10.1111/sms.12367
Volume 25
Issue S1
Start page 112
End page 125
Total pages 14
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Athletes use intravenous (IV) saline in an attempt to maximize rehydration. The diuresis from IV rehydration may be circumvented through the concomitant use of oral glycerol. We examined the effects of rehydrating with differing regimes of oral and IV fluid, with or without oral glycerol, on hydration, urine, and endocrine indices. Nine endurance-trained men were dehydrated by 4% bodyweight, then rehydrated with 150% of the fluid lost via four protocols: (a) oral=oral fluid only; (b) oral glycerol=oral fluid with added glycerol (1.5g/kg); (c) IV=50% IV fluid, 50% oral fluid; and (d) IVwith oral glycerol=50% IV fluid, 50% oral fluid with added glycerol (1.5g/kg), using a randomized, crossover design. They then completed a cycling performance test. Plasma volume restoration was highest in IV with oral glycerol>IV>oral glycerol>oral. Urine volume was reduced in both IV trials compared with oral. IV and IV with oral glycerol resulted in lower aldosterone levels during rehydration and performance, and lower cortisol levels during rehydration. IV with oral glycerol resulted in the greatest fluid retention. In summary, the IV conditions resulted in greater fluid retention compared with oral and lower levels of fluid regulatory and stress hormones compared with both oral conditions.
Keyword Aldosterone
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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