Effect of storage time of transfused plasma on early an late mortality after coronary artery bypass grafting

Van Straten, Albert H. M., Soliman Hamad, Mohamed A., Martens, Elisabeth J., Tan, M. Erwin S. H., de Wolf, Andre M., Scharnhorst, Volkher and van Zundert, Andre A. J. (2011) Effect of storage time of transfused plasma on early an late mortality after coronary artery bypass grafting. The Journal of Thoracic and Cardiovascular Surgery, 141 1: 238-243 e2. doi:10.1016/j.jtcvs.2010.05.054


Author Van Straten, Albert H. M.
Soliman Hamad, Mohamed A.
Martens, Elisabeth J.
Tan, M. Erwin S. H.
de Wolf, Andre M.
Scharnhorst, Volkher
van Zundert, Andre A. J.
Title Effect of storage time of transfused plasma on early an late mortality after coronary artery bypass grafting
Journal name The Journal of Thoracic and Cardiovascular Surgery   Check publisher's open access policy
ISSN 0022-5223
1097-685X
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.jtcvs.2010.05.054
Volume 141
Issue 1
Start page 238
End page 243 e2
Total pages 8
Place of publication Philadelphia, PA United States
Publisher Mosby
Language eng
Formatted abstract
Objectives: Because some concern has been raised about the storage time of red blood cells and outcomes after
cardiac surgery, we investigated whether longer storage time of transfused plasma increases the risk for early or
late mortality among patients who have undergone coronary artery bypass grafting.

Methods: We retrospectively analyzed the data of all 10,626 patients who underwent isolated coronary artery
bypass grafting in Catharina Hospital, Eindhoven, The Netherlands, between January 1998 and December 2007.
All patients who received at least 1 unit of plasma intraoperatively or during the first 5 postoperative days were
studied. They were divided into 3 groups (only younger plasma, only older plasma, and any older plasma groups)
according to the storage time of the plasma (cutoff point, 323 days).

Results: After we had excluded 122 patients who were unavailable for follow-up, we found that 375 of the remaining
patients (n ¼ 745) received only younger plasma 370 patients received any older plasma, and 200 patients
received only older plasma (mean follow-up, 1565 1137 days; median follow-up, 1629 days). The
storage time of plasma, when entered as either a continuous variable or a dichotomous variable, was a risk factor
for early but not late mortality. Log-rank testing revealed no statistical difference in long-term survival among
the groups.

Conclusions: Longer storage time of plasma is a risk factor for early but not late mortality among patients who
have undergone coronary artery bypass grafting.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 12 May 2015, 22:29:32 EST by Andre Van Zundert on behalf of Anaesthesiology and Critical Care - RBWH