Indications for Omega-3 Long Chain Polyunsaturated Fatty Acid in the Prevention and Treatment of Cardiovascular Disease

Nestel, Paul, Clifton, Paul, Colquhoun, David, Noakes, Manny, Mori, Trevor A., Sullivan, David and Thomas, Beth (2015) Indications for Omega-3 Long Chain Polyunsaturated Fatty Acid in the Prevention and Treatment of Cardiovascular Disease. Heart Lung and Circulation, 24 8: 769-779. doi:10.1016/j.hlc.2015.03.020


Author Nestel, Paul
Clifton, Paul
Colquhoun, David
Noakes, Manny
Mori, Trevor A.
Sullivan, David
Thomas, Beth
Title Indications for Omega-3 Long Chain Polyunsaturated Fatty Acid in the Prevention and Treatment of Cardiovascular Disease
Journal name Heart Lung and Circulation   Check publisher's open access policy
ISSN 1443-9506
1444-2892
Publication date 2015-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.hlc.2015.03.020
Volume 24
Issue 8
Start page 769
End page 779
Total pages 11
Place of publication Chatswood, NSW Australia
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Background
The National Heart Foundation of Australia (NHFA) 2008 review on omega-3 long-chain polyunsaturated fatty acids (LCPUFA) made recommendations with respect to supplementation for primary and secondary prevention of cardiovascular disease. Since then, new findings have been published regarding the relationship between omega-3 polyunsaturated fatty acids, including supplementation, and cardiovascular health.

Methods
A literature search was undertaken in PubMed and Medline, for literature published between January 1, 2007 and August 31, 2013.

Results and Conclusions
A total of eight research questions were developed and, using the National Health and Medical Research Council's evidence assessment framework, conclusions were made in relation to dietary intake of fish and omega-3 LCPUFA for cardiovascular health.

In the evidence published since 2007, this summary of evidence concludes that dietary intake of fish was found to be mostly consistent with respect to protection from heart disease and stroke. Higher fish intake was associated with lower incident rates of heart failure in addition to lower sudden cardiac death, stroke and myocardial infarction.

In relation to omega-3 LCPUFA supplementation, neither a beneficial nor adverse effect was demonstrated in primary or secondary prevention of coronary heart disease (CHD). Although the evidence continues to be positive for the role of omega-3 LCPUFA in the treatment of hypertriglyceridaemia and a modest positive benefit in heart failure. No further evidence was found to support the consumption of 2 g alpha-linolenic acid (ALA)/day over the current Australian guidelines for 1 g/day.
Keyword Cardiovascular disease
Fish consumption
Fish oil
Omega 3 polyunsaturated fatty acid supplements
Recent evidence
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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