Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis

Miller, Matthew S., Rialdi, Alexamder, Ho, Jessica Sook Yuin, Tilove, Micah, Martinez-Gil, Luis, Moshkina, Natasha P., Peralta, Zuleyma, Noel, Justine, Melegari, Camilla, Maestre, Ana M., Mitsopoulos, Panagiotis, Madrenas, Joaquin, Heinz, Sven, Benner, Chris, Young, John A. T., Feagins, Alicia R., Basler, Christopher F., Fernandez-Sesma, Ana, Becherel, Olivier J., Lavin, Martin F., Van Bakel, Harm and Marazzi, Ivan (2015) Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis. Nature Immunology, 16 5: 485-494. doi:10.1038/ni.3132

Author Miller, Matthew S.
Rialdi, Alexamder
Ho, Jessica Sook Yuin
Tilove, Micah
Martinez-Gil, Luis
Moshkina, Natasha P.
Peralta, Zuleyma
Noel, Justine
Melegari, Camilla
Maestre, Ana M.
Mitsopoulos, Panagiotis
Madrenas, Joaquin
Heinz, Sven
Benner, Chris
Young, John A. T.
Feagins, Alicia R.
Basler, Christopher F.
Fernandez-Sesma, Ana
Becherel, Olivier J.
Lavin, Martin F.
Van Bakel, Harm
Marazzi, Ivan
Title Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis
Journal name Nature Immunology   Check publisher's open access policy
ISSN 1529-2908
Publication date 2015-05-28
Year available 2015
Sub-type Article (original research)
DOI 10.1038/ni.3132
Open Access Status
Volume 16
Issue 5
Start page 485
End page 494
Total pages 10
Place of publication New York, NY United States
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived from patients with AOA2 had higher expression of antiviral mediators in response to infection than did wild-type cells. Mechanistically, we propose a model whereby SETX attenuates the activity of RNA polymerase II (RNAPII) at genes stimulated after a virus is sensed and thus controls the magnitude of the host response to pathogens and the biogenesis of various RNA viruses (e.g., influenza A virus and West Nile virus). Our data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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