Discovery of peptide drugs from natural sources

Henriques, Sonia Troeira and Craik, David J. (2015). Discovery of peptide drugs from natural sources. In Ben M. Dunn (Ed.), Peptide chemistry and drug design (pp. 203-245) Hoboken NJ, United States: John Wiley & Sons. doi:10.1002/9781118995303.ch6

Author Henriques, Sonia Troeira
Craik, David J.
Title of chapter Discovery of peptide drugs from natural sources
Title of book Peptide chemistry and drug design
Place of Publication Hoboken NJ, United States
Publisher John Wiley & Sons
Publication Year 2015
Sub-type Chapter in reference work, encyclopaedia, manual or handbook
DOI 10.1002/9781118995303.ch6
ISBN 9780470317617
Editor Ben M. Dunn
Chapter number 6
Start page 203
End page 245
Total pages 43
Total chapters 8
Collection year 2016
Language eng
Abstract/Summary All living organisms have their own arsenal of peptides that are responsible for vital biological functions. With an outstanding diversity of structures and modes of action, peptides can represent drug candidates in their natural form or serve as leads for the design of modified peptides. Some peptides extracted from natural sources are currently being used as therapeutics, whereas others are in the product pipelines of pharmaceutical companies. Nevertheless, a more general application of peptides has been delayed due to either real or perceived shortcomings in stability and bioavailability. Several chemical approaches are presently available to circumvent these potential shortcomings. This chapter emphasizes the remarkable range of applications and receptor specificities that are associated with peptides isolated from natural sources, and describes how knowledge from different disciplines is accelerating the application of peptide-based therapies.
Keyword Natural peptides
Drug design
Antimicrobial peptides
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: Non HERDC
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Created: Mon, 11 May 2015, 13:36:10 EST by Katrina Garner-Moore on behalf of Institute for Molecular Bioscience