Appropriate clinical use of human leukocyte antigen typing for coeliac disease: an Australasian perspective

Tye-Din, J. A., Cameron, D. J. S., Daveson, A. J., Day, A. S., Dellsperger, P., Hogan, C., Newnham, E. D., Shepherd, S. J., Steele, R. H., Wienholt, L. and Varney, M. D. (2015) Appropriate clinical use of human leukocyte antigen typing for coeliac disease: an Australasian perspective. Internal Medicine Journal, 45 4: 441-450. doi:10.1111/imj.12716


Author Tye-Din, J. A.
Cameron, D. J. S.
Daveson, A. J.
Day, A. S.
Dellsperger, P.
Hogan, C.
Newnham, E. D.
Shepherd, S. J.
Steele, R. H.
Wienholt, L.
Varney, M. D.
Title Appropriate clinical use of human leukocyte antigen typing for coeliac disease: an Australasian perspective
Journal name Internal Medicine Journal   Check publisher's open access policy
ISSN 1444-0903
1445-5994
Publication date 2015-04
Year available 2015
Sub-type Article (original research)
DOI 10.1111/imj.12716
Open Access Status DOI
Volume 45
Issue 4
Start page 441
End page 450
Total pages 10
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2016
Language eng
Formatted abstract
The past decade has seen human leukocyte antigen (HLA) typing emerge as a remarkably popular test for the diagnostic work-up of coeliac disease with high patient acceptance. Although limited in its positive predictive value for coeliac disease, the strong disease association with specific HLA genes imparts exceptional negative predictive value to HLA typing, enabling a negative result to exclude coeliac disease confidently. In response to mounting evidence that the clinical use and interpretation of HLA typing often deviates from best practice, this article outlines an evidence-based approach to guide clinically appropriate use of HLA typing, and establishes a reporting template for pathology providers to improve communication of results.
Keyword Coeliac disease
Diagnostics
HLA typing
European Genetics Cluster
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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