Viral bacterial co-infection of the respiratory tract during early childhood

Brealey, Jaelle C., Sly, Peter D., Young, Paul R. and Chappell, Keith J. (2015) Viral bacterial co-infection of the respiratory tract during early childhood. FEMS Microbiology Letters, 362 10: . doi:10.1093/femsle/fnv062

Author Brealey, Jaelle C.
Sly, Peter D.
Young, Paul R.
Chappell, Keith J.
Title Viral bacterial co-infection of the respiratory tract during early childhood
Journal name FEMS Microbiology Letters   Check publisher's open access policy
ISSN 0378-1097
Publication date 2015-04
Sub-type Article (original research)
DOI 10.1093/femsle/fnv062
Open Access Status
Volume 362
Issue 10
Total pages 11
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Abstract Acute respiratory infection (ARI) is an important cause of morbidity in children. Mixed aetiology is frequent, with pathogenic viruses and bacteria co-detected in respiratory secretions. However, the clinical significance of these viral/bacterial co-infections has long been a controversial topic. While severe bacterial pneumonia following influenza infection has been well described, associations are less clear among infections caused by viruses that are more common in young children, such as respiratory syncytial virus. Although assessing the overall contribution of bacteria to disease severity is complicated by the presence of many confounding factors in clinical studies, understanding the role of viral/bacterial co-infections in defining the outcome of paediatric ARI will potentially reveal novel treatment and prevention strategies, improving patient outcomes. This review summarizes current evidence for the clinical significance of respiratory viral/bacterial co-infections in young children, discusses possible mechanisms of cooperative interaction between these pathogens and highlights areas that require further investigation.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Fri, 08 May 2015, 09:57:02 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences