On the role of germ cells in mammalian gonad development: quiet passengers or back-seat drivers?

Rios-Rojas, Clarissa, Bowles, Josephine and Koopman, Peter (2015) On the role of germ cells in mammalian gonad development: quiet passengers or back-seat drivers?. Reproduction, 149 4: R181-R191. doi:10.1530/REP-14-0663


Author Rios-Rojas, Clarissa
Bowles, Josephine
Koopman, Peter
Title On the role of germ cells in mammalian gonad development: quiet passengers or back-seat drivers?
Journal name Reproduction   Check publisher's open access policy
ISSN 1470-1626
1741-7899
Publication date 2015-04-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1530/REP-14-0663
Open Access Status
Volume 149
Issue 4
Start page R181
End page R191
Total pages 11
Place of publication Bristol, United Kingdom
Publisher BioScientifica
Collection year 2016
Language eng
Abstract In addition to their role as endocrine organs, the gonads nurture and protect germ cells, and regulate the formation of gametes competent to convey the genome to the following generation. After sex determination, gonadal somatic cells use several known signalling pathways to direct germ cell development. However, the extent to which germ cells communicate back to the soma, the molecular signals they use to do so and the significance of any such signalling remain as open questions. Herein, we review findings arising from the study of gonadal development and function in the absence of germ cells in a range of organisms. Most published studies support the view that germ cells are unimportant for foetal gonadal development in mammals, but later become critical for stabilisation of gonadal function and somatic cell phenotype. However, the lack of consistency in the data, and clear differences between mammals and other vertebrates and invertebrates, suggests that the story may not be so simple and would benefit from more careful analysis using contemporary molecular, cell biology and imaging tools.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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