Smart functional nucleic acid chimeras: enabling tissue specific RNA targeting therapy

Aaldering, Lukas J., Tayeb, Hossam, Krishnan, Shilpa, Fletcher, Susan, Wilton, Stephen D. and Veedu, Rakesh N. (2015) Smart functional nucleic acid chimeras: enabling tissue specific RNA targeting therapy. RNA Biology, 12 4: 412-425. doi:10.1080/15476286.2015.1017234


Author Aaldering, Lukas J.
Tayeb, Hossam
Krishnan, Shilpa
Fletcher, Susan
Wilton, Stephen D.
Veedu, Rakesh N.
Title Smart functional nucleic acid chimeras: enabling tissue specific RNA targeting therapy
Journal name RNA Biology   Check publisher's open access policy
ISSN 1555-8584
1547-6286
Publication date 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/15476286.2015.1017234
Open Access Status Not yet assessed
Volume 12
Issue 4
Start page 412
End page 425
Total pages 48
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Collection year 2016
Language eng
Formatted abstract
A major obstacle for effective utilization of therapeutic oligonucleotides such as siRNA, antisense, antimiRs etc. is to deliver them specifically to the target tissues. Toward this goal, nucleic acid aptamers are re-emerging as a prominent class of biomolecules capable of delivering target specific therapy and therapeutic monitoring by various molecular imaging modalities. This class of short oligonucleotide ligands with high affinity and specificity are selected from a large nucleic acid pool against a molecular target of choice. Poor cellular uptake of therapeutic oligonucleotides impedes gene-targeting efficacy in vitro and in vivo. In contrast, aptamer-oligonucleotide chimeras have shown the capacity to deliver siRNA, antimiRs, small molecule drugs etc. toward various targets and showed very promising results in various studies on different diseases models. However, to further improve the bio-stability of such chimeric conjugates, it is important to introduce chemically-modified nucleic acid analogs. In this review, we highlight the applications of nucleic acid aptamers for target specific delivery of therapeutic oligonucleotides.
Keyword Aptamer chimera
Aptamer targeted delivery
Aptamers
miRNA delivery
Modified nucleotides
SiRNA delivery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
 
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