Two-dimensional graphene analogues for biomedical applications

Chen, Yu, Tan, Chaoliang, Zhang, Hua and Wang, Lianzhou (2015) Two-dimensional graphene analogues for biomedical applications. Chemical Society Reviews, 44 9: 2681-2701. doi:10.1039/C4CS00300D


Author Chen, Yu
Tan, Chaoliang
Zhang, Hua
Wang, Lianzhou
Title Two-dimensional graphene analogues for biomedical applications
Journal name Chemical Society Reviews   Check publisher's open access policy
ISSN 0306-0012
1460-4744
Publication date 2015-05-07
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1039/C4CS00300D
Open Access Status
Volume 44
Issue 9
Start page 2681
End page 2701
Total pages 21
Place of publication Cambridge, United Kingdom
Publisher RSC Publications
Collection year 2015
Language eng
Formatted abstract
The increasing demand of clinical biomedicine and fast development of nanobiotechnology has substantially promoted the generation of a variety of organic/inorganic nanosystems for biomedical applications. Biocompatible two-dimensional (2D) graphene analogues (e.g., nanosheets of transition metal dichalcogenides, transition metal oxides, g-C3N4, Bi2Se3, BN, etc.), which are referred to as 2D-GAs, have emerged as a new unique family of nanomaterials that show unprecedented advantages and superior performances in biomedicine due to their unique compositional, structural and physicochemical features. In this review, we summarize the state-of-the-art progress of this dynamically developed material family with a particular focus on biomedical applications. After the introduction, the second section of the article summarizes a range of synthetic methods for new types of 2D-GAs as well as their surface functionalization. The subsequent section provides a snapshot on the use of these biocompatible 2D-GAs for a broad spectrum of biomedical applications, including therapeutic (photothermal/photodynamic therapy, chemotherapy and synergistic therapy), diagnostic (fluorescent/magnetic resonance/computed tomography/photoacoustic imaging) and theranostic (concurrent diagnostic imaging and therapy) applications, especially on oncology. In addition, we briefly present the biosensing applications of these 2D-GAs for the detection of biomacromolecules and their in vitro/in vivo biosafety evaluations. The last section summarizes some critical unresolved issues, possible challenges/obstacles and also proposes future perspectives related to the rational design and construction of 2D-GAs for biomedical engineering, which are believed to promote their clinical translations for benefiting the personalized medicine and human health.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 18 Dec 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 98 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 29 Apr 2015, 20:35:24 EST by Professor Lianzhou Wang on behalf of School of Chemical Engineering