Basal cell carcinomas on sun-protected vs. sun-exposed body sites: a comparison of phenotypic and environmental risk factors

Khalesi, Mohammas, Whiteman, David C., Rosendahl, Cliff, Johns, Richard, Hackett, Timothy, Cameron, Alan, Waterhouse, Mary, Lucas, Robyn M., Kimlin, Michael G. and Neale, Rachel E. (2015) Basal cell carcinomas on sun-protected vs. sun-exposed body sites: a comparison of phenotypic and environmental risk factors. Photodermatology Photoimmunology and Photomedicine, 31 4: 202-211. doi:10.1111/phpp.12170


Author Khalesi, Mohammas
Whiteman, David C.
Rosendahl, Cliff
Johns, Richard
Hackett, Timothy
Cameron, Alan
Waterhouse, Mary
Lucas, Robyn M.
Kimlin, Michael G.
Neale, Rachel E.
Title Basal cell carcinomas on sun-protected vs. sun-exposed body sites: a comparison of phenotypic and environmental risk factors
Journal name Photodermatology Photoimmunology and Photomedicine   Check publisher's open access policy
ISSN 1600-0781
0905-4383
Publication date 2015-07
Sub-type Article (original research)
DOI 10.1111/phpp.12170
Volume 31
Issue 4
Start page 202
End page 211
Total pages 10
Place of publication Hoboken, NJ United States
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Background:  Basal cell carcinoma (BCC) is the most commonly diagnosed cancer in White populations. There are indications that risk factors for BCC may differ according to the anatomic site of the tumour but this is not well understood.

Purpose:  To compare phenotypic and environmental risk factors for BCCs arising on sun-protected sites with that of those on sun-exposed sites.

Methods:  We conducted a case–case study in which people who had been diagnosed with incident BCC were recruited between February 2012 and September 2013 in Brisbane, Australia.

Results:  Fair skin (OR: 4.50; 95% CI: 1.22, 16.59), having more than 15 lesions frozen/burnt off compared to less than 5 (OR: 5.68; 95% CI: 1.78, 18.08) and severe acne (OR: 5.25; 95% CI: 1.34, 20.56) were associated with increased risk of BCC on sun-protected sites. The presence of more than 5 nevi on the body was associated with decreased risk (OR: 0.28; 95% CI: 0.11, 0.71).

Conclusions:  BCCs on sun-protected sites arise as a result of excessive sun exposure, most likely combined with phenotypic susceptibility. The strong negative association with nevi also suggests that there are constitutional factors that underlie the propensity for BCCs to arise on these body sites.
Keyword Acne
Basal cell carcinoma
Nevi
Risk factors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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