Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2013: the Influenza Complications Alert Network

Cheng, Allen C., Dwyer, Dominic E., Holmes, Mark, Irving, Louis B., Brown, Simon G. A., Waterer, Grant W., Korman, Tony M., Hunter, Cameron, Hewagama, Saliya, Friedman, Nadia D., Wark, Peter A., Simpson, Graham, Upham, John W., Bowler, Simon D., Senenayake, Sanjaya N., Kotsimbos, Tom C. and Kelly, Paul M. (2014) Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2013: the Influenza Complications Alert Network. Communicable diseases intelligence quarterly report, 38 2: E143-E149.

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Author Cheng, Allen C.
Dwyer, Dominic E.
Holmes, Mark
Irving, Louis B.
Brown, Simon G. A.
Waterer, Grant W.
Korman, Tony M.
Hunter, Cameron
Hewagama, Saliya
Friedman, Nadia D.
Wark, Peter A.
Simpson, Graham
Upham, John W.
Bowler, Simon D.
Senenayake, Sanjaya N.
Kotsimbos, Tom C.
Kelly, Paul M.
Title Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2013: the Influenza Complications Alert Network
Journal name Communicable diseases intelligence quarterly report   Check publisher's open access policy
ISSN 1447-4514
1445-4866
Publication date 2014-06-01
Year available 2014
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 38
Issue 2
Start page E143
End page E149
Total pages 7
Place of publication Canberra, ACT Australia
Publisher Australian Government. Department of Health and Ageing. Office of Health Protection, Surveillance Branch
Collection year 2015
Language eng
Abstract The National Influenza Program aims to reduce serious morbidity and mortality from influenza by providing public funding for vaccination to at-risk groups. The Influenza Complications Alert Network (FluCAN) is a sentinel hospital-based surveillance program that operates at 14 sites in all states and territories in Australia. This report summarises the epidemiology of hospitalisations with confirmed influenza, estimates vaccine coverage and influenza vaccine protection against hospitalisation with influenza during the 2013 influenza season. In this observational study, cases were defined as patients admitted to one of the sentinel hospitals, with influenza confirmed by nucleic acid testing. Controls were patients who had acute respiratory illnesses who were test-negative for influenza. Vaccine effectiveness was estimated as 1 minus the odds ratio of vaccination in case patients compared with control patients, after adjusting for known confounders. During the period 5 April to 31 October 2013, 631 patients were admitted with confirmed influenza at the 14 FluCAN sentinel hospitals. Of these, 31% were more than 65 years of age, 9.5% were Indigenous Australians, 4.3% were pregnant and 77% had chronic co-morbidities. Influenza B was detected in 30% of patients. Vaccination coverage was estimated at 81% in patients more than 65 years of age but only 49% in patients aged less than 65 years with chronic comorbidities. Vaccination effectiveness against hospitalisation with influenza was estimated at 50% (95% confidence interval: 33%, 63%, P<0.001). We detected a significant number of hospital admissions with confirmed influenza in a national observational study. Vaccine coverage was incomplete in at-risk groups, particularly non-elderly patients with medical comorbidities. Our results suggest that the seasonal influenza vaccine was moderately protective against hospitalisation with influenza in the 2013 season.
Keyword Influenza
Vaccine effectiveness
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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