Changes in chronotype after stroke: a pilot study

Kantermann, Thomas, Meisel, Andreas, Fitzthum, Katharina, Penzel, Thomas, Fietze, Ingo and Ulm, Lena (2015) Changes in chronotype after stroke: a pilot study. Frontiers in Neurology, 5 JAN: 1-7. doi:10.3389/fneur.2014.00287

Author Kantermann, Thomas
Meisel, Andreas
Fitzthum, Katharina
Penzel, Thomas
Fietze, Ingo
Ulm, Lena
Title Changes in chronotype after stroke: a pilot study
Journal name Frontiers in Neurology   Check publisher's open access policy
ISSN 1664-2295
Publication date 2015-01-12
Sub-type Article (original research)
DOI 10.3389/fneur.2014.00287
Open Access Status DOI
Volume 5
Issue JAN
Start page 1
End page 7
Total pages 7
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2016
Language eng
Formatted abstract
This study aimed to elucidate associations between stroke onset and severity as well as
chronotype (phase of entrainment) and internal time of stroke. Fifty-six first-ever ischemic
stroke patients participated in a cross-sectional study assessing chronotype (mid-sleep on
work-free days corrected for sleep deficit on workdays; MSFsc) by applying the Munich
ChronoType Questionnaire (MCTQ).The MCTQ was completed twice, on average 68 ± 24
(SD) days post stroke and retrospectively for the time before stroke. To assess the impact
of stroke in relation to internal time, InTstroke was calculated as MSFsc minus local time
of stroke. Stroke severity was assessed via the standard clinical National Institute Health
Stroke Scale (NIHSS) and modified Ranking Scale (mRS), both at hospital admission and
discharge. Overall, most strokes occurred between noon and midnight. There was no significant
association between MSFsc and stroke onset. MSFsc changed significantly after
stroke, especially in patients with more severe strokes. Changes in MSFsc varied with
InTstroke – the earlier the internal time of a stroke relative to MSFsc-before-stroke, the more
MSFsc advanced after stroke. In addition, we provide first evidence that MSFsc changes
varied between stroke locations. Larger trials are needed to confirm these findings.
Keyword Chronotype
Internal time
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
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