Crusted scabies is associated with increased IL-17 secretion by skin T cells

Liu, X., Walton, S. F., Murray, H. C., King, M., Kelly, A., Holt, D. C., Currie, B. J., McCarthy, J. S. and Mounsey, K. E. (2014) Crusted scabies is associated with increased IL-17 secretion by skin T cells. Parasite Immunology, 36 11: 594-604. doi:10.1111/pim.12129


Author Liu, X.
Walton, S. F.
Murray, H. C.
King, M.
Kelly, A.
Holt, D. C.
Currie, B. J.
McCarthy, J. S.
Mounsey, K. E.
Title Crusted scabies is associated with increased IL-17 secretion by skin T cells
Journal name Parasite Immunology   Check publisher's open access policy
ISSN 1365-3024
0141-9838
Publication date 2014-11-01
Year available 2014
Sub-type Article (original research)
DOI 10.1111/pim.12129
Open Access Status
Volume 36
Issue 11
Start page 594
End page 604
Total pages 11
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2015
Language eng
Formatted abstract
Scabies is an ectoparasitic infestation by the mite Sarcoptes scabiei. Although commonly self-limiting, a fraction of patients develop severely debilitating crusted scabies. The immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans is difficult. We utilized a porcine model to compare cellular immune responses in peripheral blood and skin of pigs with different clinical manifestations of scabies (n = 12), and in uninfected controls (n = 6). Although clinical symptoms were not evident until at least 4 weeks post-infestation, the numbers of peripheral IFNγ-secreting CD4+ T cells and γδ T cells increased in infected pigs from week 1 post-infestation. γδ T cells remained increased in the blood at week 15 post-infestation. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, γδ T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development. Given the potential of anti-IL-17 immunotherapy demonstrated for other inflammatory skin diseases, this study may provide a novel therapeutic avenue for patients with recurrent crusted scabies.
Keyword Crusted scabies
IL-17
Scabies
γδ T cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2015 Collection
School of Medicine Publications
 
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