Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the sun exposure and vitamin D supplementation (SEDS) Study

Hartley, Mica, Hoare, Samuel, Lithander, Fiona E., Neale, Rachel E., Hart, Prue H., Gorman, Shelley, Gies P., Sherriff, Jill, Swaminathan, Ashwin, Beilin, Lawrence J., Mori, Trevor A., King, Laura, Black, Lucinda J., Marshall, Kushani, Xiang, Fan, Wyatt, Candy, King, Kerryn, Slevin, Terry, Pandeya, Nirmala and Lucas, Robyn M. (2015) Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the sun exposure and vitamin D supplementation (SEDS) Study. BMC Public Health, 15 1: 1-9. doi:10.1186/s12889-015-1461-7


Author Hartley, Mica
Hoare, Samuel
Lithander, Fiona E.
Neale, Rachel E.
Hart, Prue H.
Gorman, Shelley
Gies P.
Sherriff, Jill
Swaminathan, Ashwin
Beilin, Lawrence J.
Mori, Trevor A.
King, Laura
Black, Lucinda J.
Marshall, Kushani
Xiang, Fan
Wyatt, Candy
King, Kerryn
Slevin, Terry
Pandeya, Nirmala
Lucas, Robyn M.
Title Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the sun exposure and vitamin D supplementation (SEDS) Study
Journal name BMC Public Health   Check publisher's open access policy
ISSN 1471-2458
Publication date 2015-02-10
Sub-type Article (original research)
DOI 10.1186/s12889-015-1461-7
Open Access Status DOI
Volume 15
Issue 1
Start page 1
End page 9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2016
Language eng
Formatted abstract
Background:  Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D (25(OH)D) concentration of less than 50 nmol/L) is also common. Vitamin D deficiency may be a risk factor for a range of diseases. However, the optimal strategies to achieve and maintain vitamin D adequacy (sun exposure, vitamin D supplementation or both), and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D, remain unclear.
The Sun Exposure and Vitamin D Supplementation (SEDS) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency, and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function.

Methods/Design:  The SEDS Study is a multi-centre, randomised controlled trial of two different daily doses of vitamin D supplementation, and placebo, in conjunction with guidance on two different patterns of sun exposure. Participants recruited from across Australia are aged 18–64 years and have a recent vitamin D test result showing a serum 25(OH)D level of 40–60 nmol/L.

Discussion:  This paper discusses the rationale behind the study design, and considers the challenges but necessity of data collection within a non-institutionalised adult population, in order to address the study aims. We also discuss the challenges of participant recruitment and retention, ongoing engagement of referring medical practitioners and address issues of compliance and participant retention.

Trial registration:  Australia New Zealand Clinical Trials Registry: ACTRN12613000290796 webcite Registered 14 March 2013.
Keyword Sun exposure
Vitamin D
Immune function
Cardio-metabolic function
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 115.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
 
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