Opportunities and pitfalls of molecular testing for detecting sexually transmitted pathogens

Trembizki, Ella, Costa, Anna-Maria G., Tabrizi, Sepehr N., Whiley, David M. and Twin, Jimmy (2015) Opportunities and pitfalls of molecular testing for detecting sexually transmitted pathogens. Pathology, 47 3: 219-226. doi:10.1097/PAT.0000000000000239


Author Trembizki, Ella
Costa, Anna-Maria G.
Tabrizi, Sepehr N.
Whiley, David M.
Twin, Jimmy
Title Opportunities and pitfalls of molecular testing for detecting sexually transmitted pathogens
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
1465-3931
Publication date 2015-04
Year available 2015
Sub-type Article (original research)
DOI 10.1097/PAT.0000000000000239
Volume 47
Issue 3
Start page 219
End page 226
Total pages 8
Place of publication London, United Kingdom
Publisher Lippincott Williams & Wilkins
Collection year 2016
Language eng
Formatted abstract
Summary: In the last 20 years, nucleic acid amplification tests (NAATs) have gradually replaced traditional methods for the detection of sexually transmitted infections. NAAT technology comes with some considerable benefits for diagnosis, including increased sensitivity, rapid result turnaround and suitability for high throughput screening of asymptomatic individuals using more-readily available specimens. However, the transition to NAAT has not come without its problems. False-negative and false-positive results have been reported owing to various technical issues. Furthermore, increased reliance on NAATs for diagnosis have created the need to develop NAAT-based methods to inform treatment, being an area that presents its own set of challenges. In this review article, we explore NAAT-based detection of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Trichomonas vaginalis. In doing so, we consider the benefits and limitations of NAAT-based technology and highlight areas where further research and development is in need.
Keyword Chlamydia
Gonorrhoea
Molecular
Mycoplasma
NAAT
PCR
Trichomonas
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Children's Medical Research Institute Publications
Official 2016 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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