The effect of immune status, age and genetic background on induction of oral tolerance to actinomyces viscosus in mice

Sosroseno, Wihaskoro, Herminajeng, Endang and Bird, Phil (2015) The effect of immune status, age and genetic background on induction of oral tolerance to actinomyces viscosus in mice. Biomedicine & Pharmacotherapy, 70 C: 294-298. doi:10.1016/j.biopha.2014.12.039


Author Sosroseno, Wihaskoro
Herminajeng, Endang
Bird, Phil
Title The effect of immune status, age and genetic background on induction of oral tolerance to actinomyces viscosus in mice
Journal name Biomedicine & Pharmacotherapy   Check publisher's open access policy
ISSN 0753-3322
1950-6007
Publication date 2015-03
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.biopha.2014.12.039
Open Access Status
Volume 70
Issue C
Start page 294
End page 298
Total pages 5
Place of publication Issy les Moulineaux, France
Publisher Elsevier Masson
Collection year 2016
Language eng
Formatted abstract
The aim of the present study was to determine the effect of immune status, age and genetic background on the induction of oral tolerance to Actinomyces viscosus. Suppression of delayed type hypersensitivity (DTH) response and antigen-specific serum antibody levels could be induced in DBA/2 mice intragastrically and systemically immunized with A. viscocus, suggesting the induction of oral tolerance. In contrast, this immune suppression could be abrogated if the animals had been systemically immunized prior to the induction of oral tolerance with the same bacterium. Long-term systemic immunization prior to intragastric immunization with A. viscocus suppressed DTH response only. Cell transfer of this group of animals also suppressed DTH response in the donors, indicating the action of suppressor cells for inhibition of DTH response. Furthermore, oral tolerance to A. viscocus failed to occur in mice aged at 3 days and 1, 2, 4, 6 and 36 weeks old. Mice bearing H-2d haplotype were the most susceptible to oral tolerization, followed by H-2b and H-2k. Therefore, the results of the presence study suggest that the induction of oral tolerance to A. viscosus in mice may be dependence on the immune status and genetic background but not age.
Keyword Delayed type hypersensitivity
Immune status
Oral tolerance
Root Surface Caries
Immunological-tolerance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Veterinary Science Publications
 
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