A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats

Kumar, Senthil Arun, Magnusson, Marie, Ward, Leigh C., Paul, Nicholas A. and Brown, Lindsay (2015) A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats. Nutrients, 7 4: 2771-2787. doi:10.3390/nu7042771


Author Kumar, Senthil Arun
Magnusson, Marie
Ward, Leigh C.
Paul, Nicholas A.
Brown, Lindsay
Title A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats
Formatted title
A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats
Journal name Nutrients   Check publisher's open access policy
ISSN 2072-6643
Publication date 2015-04-14
Sub-type Article (original research)
DOI 10.3390/nu7042771
Open Access Status DOI
Volume 7
Issue 4
Start page 2771
End page 2787
Total pages 17
Place of publication Basel, Switzerland
Publisher M D P I
Collection year 2016
Language eng
Formatted abstract
This study investigated the responses to a green algae mixture of Scenedesmus dimorphus and Schroederiella apiculata (SC) containing protein (46.1% of dry algae), insoluble fibre (19.6% of dry algae), minerals (3.7% of dry algae) and omega-3 fatty acids (2.8% of dry algae) as a dietary intervention in a high carbohydrate, high fat diet-induced metabolic syndrome model in four groups of male Wistar rats. Two groups were fed with a corn starch diet containing 68% carbohydrates as polysaccharides, while the other two groups were fed a diet high in simple carbohydrates (fructose and sucrose in food, 25% fructose in drinking water, total 68%) and fats (saturated and trans fats from beef tallow, total 24%). High carbohydrate, high fat-fed rats showed visceral obesity with hypertension, insulin resistance, cardiovascular remodelling, and nonalcoholic fatty liver disease. SC supplementation (5% of food) lowered total body and abdominal fat mass, increased lean mass, and attenuated hypertension, impaired glucose and insulin tolerance, endothelial dysfunction, infiltration of inflammatory cells into heart and liver, fibrosis, increased cardiac stiffness, and nonalcoholic fatty liver disease in the high carbohydrate, high fat diet-fed rats. This study suggests that the insoluble fibre or protein in SC helps reverse diet-induced metabolic syndrome.
Keyword Visceral obesity
Metabolic symptoms
Microalgae
Insoluble fibre
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 17 Apr 2015, 13:59:12 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences