Manufacturing perinatal stem cells for clinical applications

Heazlewood, Celena F., Iliac, Nina and Atkinson, Kerry (2014). Manufacturing perinatal stem cells for clinical applications. In Anthony Atala and Sean V. Murphy (Ed.), Perinatal stem cells (pp. 339-346) New York, United States: Springer. doi:10.1007/978-1-4939-1118-9_30


Author Heazlewood, Celena F.
Iliac, Nina
Atkinson, Kerry
Title of chapter Manufacturing perinatal stem cells for clinical applications
Title of book Perinatal stem cells
Place of Publication New York, United States
Publisher Springer
Publication Year 2014
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-4939-1118-9_30
Open Access Status
ISBN 9781493911172
9781493911189
Editor Anthony Atala
Sean V. Murphy
Chapter number 30
Start page 339
End page 346
Total pages 8
Total chapters 32
Collection year 2015
Language eng
Abstract/Summary Mesenchymal cells are being increasingly explored in clinical trials. They are promising candidates for allogeneic “off-the-shelf” cellular therapy because they preferentially migrate to sites of inflammation and injury and can be transplanted into patients without the need for immune suppression. We used mesenchymal stromal cells derived from term placenta for our clinical trial program exploring the use of these cells. In this chapter we describe the methods that we utilised to harvest and administer these cells according to the Code of Good Manufacturing Practice principles and according to policies and procedures of our internal Quality Management System based on the International Organisation for Standardisation (ISO) requirements. Although hematopoietic stem cells are present in placenta, this chapter focuses solely on mesenchymal cells in the term placenta.
Keyword Stem cells
Cell biology
Reproductive medicine
Obstetrics/perinatology
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: UQ Centre for Clinical Research Publications
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Created: Thu, 16 Apr 2015, 18:00:32 EST by Mary-Anne Marrington on behalf of UQ Centre for Clinical Research