Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Arner, Erik, Beckhouse, Anthony, Briggs, James, Ovchinnikov, Dmitry, Wolvetang, Ernst, Wells, Christine and FANTOM Consortium (2015) Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science, 347 6225: 1010-1014. doi:10.1126/science.1259418

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Author Arner, Erik
Beckhouse, Anthony
Briggs, James
Ovchinnikov, Dmitry
Wolvetang, Ernst
Wells, Christine
FANTOM Consortium
Title Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 2015-02-27
Sub-type Article (original research)
DOI 10.1126/science.1259418
Volume 347
Issue 6225
Start page 1010
End page 1014
Total pages 5
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Collection year 2016
Language eng
Formatted abstract
Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of genes has not been previously studied en masse. Exploiting the fact that active promoters and enhancers are transcribed, we simultaneously measured their activity in 19 human and 14 mouse time courses covering a wide range of cell types and biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription factors, dominated the earliest responses. Binding sites for key lineage transcription factors were simultaneously overrepresented in enhancers and promoters active in each cellular system. Our data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 66 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 74 times in Scopus Article | Citations
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Created: Thu, 16 Apr 2015, 17:49:30 EST by Dr Dmitry Ovchinnikov on behalf of Aust Institute for Bioengineering & Nanotechnology