Retrospective 2D frontomaxillary facial angle measurements in trisomy 21 fetuses during routine first-trimester screening

Alphonse, Jennifer, Cox, Jenny, Clarke, Jillian L., Schluter, Philip J. and McLennan, Andrew (2015) Retrospective 2D frontomaxillary facial angle measurements in trisomy 21 fetuses during routine first-trimester screening. Sonography, 2 1: 8-13. doi:10.1002/sono.12016

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Author Alphonse, Jennifer
Cox, Jenny
Clarke, Jillian L.
Schluter, Philip J.
McLennan, Andrew
Title Retrospective 2D frontomaxillary facial angle measurements in trisomy 21 fetuses during routine first-trimester screening
Journal name Sonography   Check publisher's open access policy
ISSN 2054-6750
Publication date 2015-03
Sub-type Article (original research)
DOI 10.1002/sono.12016
Volume 2
Issue 1
Start page 8
End page 13
Total pages 6
Editor Glenda McLean
Place of publication Richmond, VIC, Australia
Publisher Wiley Publishing Asia
Collection year 2016
Language eng
Formatted abstract
Objective The aim of this study is to assess the feasibility and utility of retrospective frontomaxillary facial angle measurement on two-dimensional (2D) images from confirmed trisomy 21 fetuses.

Materials and methods Over a 27-month period, stored 2D fetal profile images taken during routine first-trimester screening were assessed. A single experienced operator utilising an offline digital measurement tool measured the frontomaxillary facial angle of 55 karyotypically proven trisomy 21 fetuses. The resultant measurements were compared with 2D prospectively collected frontomaxillary facial angle measurements in both trisomy 21 and euploid fetuses, which were also performed by the same operator.

Results The mean maternal age of both trisomy 21 cohorts [37 years old (prospective) and 37.7 years old (retrospective)] was similar (p = 0.72), and both were greater than those of the euploid group (32.2 years old) (p < 0.001). The median frontomaxillary facial angle measurement of the retrospective trisomy 21 cohort (90.5°) was greater than that of the euploid fetus group (87.1°) (p < 0.001) but has no difference to the median of the measurements collected prospectively from trisomy 21 fetuses (91.1°) (p = 0.86).

Conclusion Overall, trisomy 21 fetuses have a larger frontomaxillary facial angle than euploid fetuses. Frontomaxillary facial angle measurements performed retrospectively in 2D were not different to prospective 2D frontomaxillary facial angle measurements.
Keyword Frontomaxillary facial angle
2D
3D
Ultrasound
Trisomy 21
Screening
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
School of Nursing, Midwifery and Social Work Publications
 
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Created: Wed, 15 Apr 2015, 14:34:54 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work