Ribifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activity

Pinto, Meri Emili F., Batista, Joao M., Koehbach, Johannes, Gaur, Pratibha, Sharma, Abhinay, Nakabashi, Myna, Cilli, Eduardo Maffud, Giesel, Guilherme M., Verli, Hugo, Gruber, Christian W., Blanch, Ewan W., Tavares, Joseam F., da Silva, Marcelo S., Garcia, Celia R. S. and Bolzani, Vanderlan S. (2015) Ribifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activity. Journal of Natural Products, 78 3: 374-380. doi:10.1021/np5007668


Author Pinto, Meri Emili F.
Batista, Joao M.
Koehbach, Johannes
Gaur, Pratibha
Sharma, Abhinay
Nakabashi, Myna
Cilli, Eduardo Maffud
Giesel, Guilherme M.
Verli, Hugo
Gruber, Christian W.
Blanch, Ewan W.
Tavares, Joseam F.
da Silva, Marcelo S.
Garcia, Celia R. S.
Bolzani, Vanderlan S.
Title Ribifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activity
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
1520-6025
Publication date 2015-03-27
Year available 2015
Sub-type Article (original research)
DOI 10.1021/np5007668
Open Access Status
Volume 78
Issue 3
Start page 374
End page 380
Total pages 7
Place of publication Washington, DC United States
Publisher American Chemical Society
Collection year 2016
Language eng
Formatted abstract
A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 μM) against the Plasmodium falciparum strain 3D7.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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