The urokinase receptor and the regulation of cell proliferation

Mazzieri, R and Blasi, F (2005) The urokinase receptor and the regulation of cell proliferation. Thrombosis and Haemostasis, 93 4: 641-646. doi:10.1160/TH05-01-0021


Author Mazzieri, R
Blasi, F
Title The urokinase receptor and the regulation of cell proliferation
Journal name Thrombosis and Haemostasis   Check publisher's open access policy
ISSN 0340-6245
Publication date 2005
Sub-type Article (original research)
DOI 10.1160/TH05-01-0021
Volume 93
Issue 4
Start page 641
End page 646
Total pages 6
Language eng
Subject 2720 Hematology
Abstract The urokinase receptor is a multifunctional receptor modulating both proteolytic dependent and independent processes. It binds the extracellular proteolytic enzyme urokinase and engages lateral interactions with several transmembrane receptors, including integrins and the EGFR. Both, by initiating a proteolytic cascade acting on the extracellular matrix components, and by regulating the activity of important signal transducers, uPAR participates not only in the modulation of cell-cell and cell-extracellular matrix interactions, but also in the control of extracellular signals determining the proliferative state of a cell. Alteration of such a complex and finely modulated mechanism results in unregulated cell proliferation and altered tissue organization, typically associated with tumor progression.
Keyword Metastasis
Proliferation
Tumors
Urokinase receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
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