Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies

Roberts, Stuart K., Mitchell, Joanne, Leung, Reynold, Booth, David, Bollipo, Steven, Ostapowicz, George, Sloss, Andrew, McCaughan, Geoffrey W., Dore, Gregory J., Thompson, Alexander, Crawford, Darrell H. G., Sievert, William, Weltman, Martin, Cheng, Wendy and George, Jacob (2014) Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies. Journal of Gastroenterology and Hepatology (Australia), 29 1: 179-184. doi:10.1111/jgh.12424

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Author Roberts, Stuart K.
Mitchell, Joanne
Leung, Reynold
Booth, David
Bollipo, Steven
Ostapowicz, George
Sloss, Andrew
McCaughan, Geoffrey W.
Dore, Gregory J.
Thompson, Alexander
Crawford, Darrell H. G.
Sievert, William
Weltman, Martin
Cheng, Wendy
George, Jacob
Title Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies
Journal name Journal of Gastroenterology and Hepatology (Australia)   Check publisher's open access policy
ISSN 0815-9319
1440-1746
Publication date 2014-01
Year available 2014
Sub-type Article (original research)
DOI 10.1111/jgh.12424
Open Access Status
Volume 29
Issue 1
Start page 179
End page 184
Total pages 6
Place of publication Richmond VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2015
Language eng
Formatted abstract
Background and Aims: The aim of this study was to examine the distribution of interferon lambda-3 (IFN-λ3) gene polymorphisms in previously untreated Australian patients with genotype 1 (Gt1) chronic hepatitis C (CHC) and to compare the IFN-λ3 genotype frequency among the different ethnic populations.

Methods: This was a prospective, multicenter, observational study undertaken by the Australian Liver Association Clinical Research Network. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment. IFN-λ3 single nucleotide polymorphisms were genotyped by the Applied Biosystems's Taqman single nucleotide polymorphism genotyping assay.

Results: Between May 2012 and June 2012, 1132 patients were recruited from 38 treatment clinics across Australia. Also, 561 subjects from the CHARIOT (collaborative group hepatitis C study using high dose Pegasys RBV Induction dose in genotype one) study of high-dose interferon who had baseline serum available were retrospectively tested. The overall frequency of IFN-λ3 rs12979860 CC/CT/TT genotypes was 36%, 52%, and 12%, and that of rs8099917 TT/TG/GG genotypes was 54%, 41%, and 5%, respectively. The prevalence of the favorable IFN-λ3 rs12979860 CC and rs8099917 TT genotypes in Causcasians, Asians, Aboriginals, Maori/Pacific Islanders, and Mediterraneans was 32% and 52%, 80% and 86%, 33% and 63%, 77% and 88%, and 19% and 29%, respectively. Compared with Caucasians, the frequency of IFN-λ3 CC was significantly higher among Asians (P<0.0001) and Maori/Pacific Islander subjects (P<0.0001).

Conclusions: The distribution of IFN-λ3 polymorphisms among untreated patients with Gt1 CHC in Australia appears similar to that reported from North America. The frequency of the favorable response alleles varies considerably according to ethnicity, being more common in self-reported Asians and Maori/Pacific Islanders than Caucasians, Aboriginals, and Mediterraneans.
Keyword Chronic hepatitis C
HCV genotype 1
IFN-λ3 (Interleukin 28B)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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