The innate resistance of Trypanosoma copemani to human serum

Austen, J. M., Ryan, U., Ditcham, W. G., Friend, J. A. and Reid, S. A. (2015) The innate resistance of Trypanosoma copemani to human serum. Experimental Parasitology, 153 105-110. doi:10.1016/j.exppara.2015.03.022

Author Austen, J. M.
Ryan, U.
Ditcham, W. G.
Friend, J. A.
Reid, S. A.
Title The innate resistance of Trypanosoma copemani to human serum
Formatted title
The innate resistance of Trypanosoma copemani to human serum
Journal name Experimental Parasitology   Check publisher's open access policy
ISSN 0014-4894
Publication date 2015-06
Sub-type Article (original research)
DOI 10.1016/j.exppara.2015.03.022
Open Access Status
Volume 153
Start page 105
End page 110
Total pages 6
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2016
Language eng
Abstract Trypanosoma copemani is known to be infective to a variety of Australian marsupials. Characterisation of this parasite revealed the presence of stercorarian-like life-cycle stages in culture, which are similar to T. rangeli and T. cruzi. The blood incubation infectivity test (BIIT) was adapted and used to determine if T. copemani, like T. cruzi and T. rangeli, has the potential to grow in the presence of human serum. To eliminate any effects of anticoagulants on the complement system and on human high density lipoprotein (HDL), only fresh whole human blood was used. Trypanosoma copemani was observed by microscopy in all human blood cultures from day 5 to day 19 post inoculation (PI). The mechanism for normal human serum (NHS) resistance in T. copemani is not known. The results of this study show that at least one native Australian trypanosome species may have the potential to be infective for humans.
Keyword BIIT
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 10 Apr 2015, 14:50:10 EST by Simon Reid on behalf of School of Public Health