Relationship of body mass index with total mortality, cardiovascular mortality, and myocardial infarction after coronary revascularization: Evidence from a meta-analysis

Sharma, Abhishek, Vallakati, Ajay, Einstein, Andrew J., Lavie, Carl J., Arbab-Zadeh, Armin, Lopez-Jimenez, Francisco, Mukherjee, Debabrata and Lichstein, Edgar (2014) Relationship of body mass index with total mortality, cardiovascular mortality, and myocardial infarction after coronary revascularization: Evidence from a meta-analysis. Mayo Clinic Proceedings, 89 8: 1080-1100. doi:10.1016/j.mayocp.2014.04.020


Author Sharma, Abhishek
Vallakati, Ajay
Einstein, Andrew J.
Lavie, Carl J.
Arbab-Zadeh, Armin
Lopez-Jimenez, Francisco
Mukherjee, Debabrata
Lichstein, Edgar
Title Relationship of body mass index with total mortality, cardiovascular mortality, and myocardial infarction after coronary revascularization: Evidence from a meta-analysis
Journal name Mayo Clinic Proceedings   Check publisher's open access policy
ISSN 1942-5546
0025-6196
Publication date 2014
Sub-type Article (original research)
DOI 10.1016/j.mayocp.2014.04.020
Open Access Status
Volume 89
Issue 8
Start page 1080
End page 1100
Total pages 21
Place of publication New York, NY, U.S.A.
Publisher Elsevier Ltd
Collection year 2015
Language eng
Subject 2700 Medicine
Abstract Objective To investigate the relationship of body mass index (BMI) with total mortality, cardiovascular (CV) mortality, and myocardial infarction (MI) after coronary revascularization procedures (coronary artery bypass grafting [CABG] and percutaneous coronary intervention [PCI]). Patients and Methods Systematic search of studies was conducted using PubMed, CINAHL, Cochran CENTRAL, Scopus, and the Web of Science databases. We identified studies reporting the rate of MI, CV mortality, and total mortality among coronary artery disease patients' postcoronary revascularization procedures in various BMI categories: less than 20 (underweight), 20-24.9 (normal reference), 25-29.9 (overweight), 30-34.9 (obese), and 35 or more (severely obese). Event rates were compared using a random effects model assuming interstudy heterogeneity. Results A total of 36 studies (12 CABG; 26 PCI) were selected for final analyses. The risk of total mortality (relative risk [RR], 2.59; 95% CI, 2.09-3.21), CV mortality (RR, 2.67; 95% CI, 1.63-4.39), and MI (RR, 1.79; 95% CI, 1.28-2.50) was highest among patients with low BMI at the end of a mean follow-up period of 1.7 years. The risk of CV mortality was lowest among overweight patients (RR, 0.81; 95% CI, 0.68-0.95). Increasing degree of adiposity as assessed by BMI had a neutral effect on the risk of MI for overweight (RR, 0.92; 95% CI, 0.84-1.01), obese (RR, 0.99; 95% CI, 0.85-1.15), and severely obese (RR, 0.93; 95% CI, 0.78-1.11) patients. Conclusion After coronary artery disease revascularization procedures (PCI and CABG), the risk of total mortality, CV mortality, and MI was highest among underweight patients as defined by low BMI and CV mortality was lowest among overweight patients.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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Created: Wed, 08 Apr 2015, 12:04:42 EST by Matthew Lamb on behalf of School of Medicine