Cytomegalovirus disease in immunocompetent adults

Lancini, Daniel, Faddy, Helen M., Flower, Robert and Hogan, Chris (2014) Cytomegalovirus disease in immunocompetent adults. The Medical Journal of Australia, 201 10: 578-580. doi:10.5694/mja14.00183

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Author Lancini, Daniel
Faddy, Helen M.
Flower, Robert
Hogan, Chris
Title Cytomegalovirus disease in immunocompetent adults
Journal name The Medical Journal of Australia   Check publisher's open access policy
ISSN 1326-5377
0025-729X
Publication date 2014-11-17
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.5694/mja14.00183
Open Access Status
Volume 201
Issue 10
Start page 578
End page 580
Total pages 3
Place of publication Strawberry Hills, NSW, Australia
Publisher Australasian Medical Publishing Company
Collection year 2015
Language eng
Formatted abstract
Cytomegalovirus (CMV) is a highly prevalent and globally distributed virus.

CMV infection in healthy adults is usually asymptomatic or causes a mild mononucleosis-like syndrome.

CMV disease causes significant morbidity and mortality in neonates and severely immunocompromised adults.

CMV disease can present with a wide range of manifestations, with colitis being the most common.

The incidence of severe CMV disease in immunocompetent adults appears to be greater than previously thought, which may be partly due to immune dysfunction related to comorbidities such as kidney disease or diabetes mellitus.

CMV disease can mimic an array of alternative diagnoses and pose a significant diagnostic challenge, especially in immunocompetent adults, leading to delayed diagnosis, adverse health outcomes and unnecessary financial expense.

Non-invasive testing for CMV is widely available and can facilitate early diagnosis if used appropriately.

Although limited, current evidence suggests that targeted antiviral therapy with ganciclovir or valganciclovir is appropriate for severe CMV disease in immunocompetent adults.
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Official Audit
School of Medicine Publications
 
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