Exposing asymmetric gray matter vulnerability in amyotrophic lateral sclerosis

Devine, Matthew S., Pannek, Kerstin, Coulthard, Alan, McCombe, Pamela A., Rose, Stephen E. and Henderson, Robert D. (2015) Exposing asymmetric gray matter vulnerability in amyotrophic lateral sclerosis. NeuroImage: Clinical, 7 782-787. doi:10.1016/j.nicl.2015.03.006

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Devine, Matthew S.
Pannek, Kerstin
Coulthard, Alan
McCombe, Pamela A.
Rose, Stephen E.
Henderson, Robert D.
Title Exposing asymmetric gray matter vulnerability in amyotrophic lateral sclerosis
Journal name NeuroImage: Clinical   Check publisher's open access policy
ISSN 2213-1582
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.nicl.2015.03.006
Open Access Status DOI
Volume 7
Start page 782
End page 787
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract Limb weakness in amyotrophic lateral sclerosis (ALS) is typically asymmetric. Previous studies have identified an effect of limb dominance on onset and spread of weakness, however relative atrophy of dominant and non-dominant brain regions has not been investigated. Our objective was to use voxel-based morphometry (VBM) to explore gray matter (GM) asymmetry in ALS, in the context of limb dominance. 30 ALS subjects were matched with 17 healthy controls. All subjects were right-handed. Each underwent a structural MRI sequence, from which GM segmentations were generated. Patterns of GM atrophy were assessed in ALS subjects with first weakness in a right-sided limb (n = 15) or left-sided limb (n = 15). Within each group, a voxelwise comparison was also performed between native and mirror GM images, to identify regions of hemispheric GM asymmetry. Subjects with ALS showed disproportionate atrophy of the dominant (left) motor cortex hand area, irrespective of the side of first limb weakness (p < 0.01). Asymmetric atrophy of the left somatosensory cortex and temporal gyri was only observed in ALS subjects with right-sided onset of limb weakness. Our VBM protocol, contrasting native and mirror images, was able to more sensitively detect asymmetric GM pathology in a small cohort, compared with standard methods. These findings indicate particular vulnerability of dominant upper limb representation in ALS, supporting previous clinical studies, and with implications for cortical organisation and selective vulnerability.
Keyword Motor neuron disease
Amyotrophic lateral sclerosis
Voxel-based morphometry
Limb dominance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 07 Apr 2015, 01:39:24 EST by System User on behalf of School of Medicine