Insulin secretion from beta cells within intact islets: Location matters

Do, Oanh Hoang and Thorn, Peter (2015) Insulin secretion from beta cells within intact islets: Location matters. Clinical and Experimental Pharmacology and Physiology, 42 4: 406-414. doi:10.1111/1440-1681.12368


Author Do, Oanh Hoang
Thorn, Peter
Title Insulin secretion from beta cells within intact islets: Location matters
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 1440-1681
Publication date 2015-04
Year available 2015
Sub-type Article (original research)
DOI 10.1111/1440-1681.12368
Open Access Status
Volume 42
Issue 4
Start page 406
End page 414
Total pages 9
Place of publication Richmond, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2016
Language eng
Abstract The control of hormone secretion is central to body homeostasis, and its dysfunction is important in many diseases. The key cellular steps that lead to hormone secretion have been identified, and the stimulus-secretion pathway is understood in outline for many endocrine cells. In the case of insulin secretion from pancreatic beta cells, this pathway involves the uptake of glucose, cell depolarization, calcium entry, and the triggering of the fusion of insulin-containing granules with the cell membrane. The wealth of information on the control of insulin secretion has largely been obtained from isolated single-cell studies. However, physiologically, beta cells exist within the islets of Langerhans, with structural and functional specializations that are not preserved in single-cell cultures. This review focuses on recent work that is revealing distinct aspects of insulin secretion from beta cells within the islet.
Keyword Beta cells
Calcium
Diabetes
Exocytosis
Insulin
Islets
Synapse
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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