Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from streptomyces sp.

Rho, Jung-Rae, Subramaniam, Gurusamy, Choi, Hyukjae, Kim, Eun-Hee, Ng, Sok Peng, Yoganathan, K., Ng, Siewbee, Buss, Antony D., Butler, Mark S. and Gerwick, William H. (2015) Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from streptomyces sp.. Organic Letters, 17 6: 1377-1380. doi:10.1021/acs.orglett.5b00068


Author Rho, Jung-Rae
Subramaniam, Gurusamy
Choi, Hyukjae
Kim, Eun-Hee
Ng, Sok Peng
Yoganathan, K.
Ng, Siewbee
Buss, Antony D.
Butler, Mark S.
Gerwick, William H.
Title Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from streptomyces sp.
Journal name Organic Letters   Check publisher's open access policy
ISSN 1523-7052
1523-7060
Publication date 2015-02-27
Year available 2015
Sub-type Article (original research)
DOI 10.1021/acs.orglett.5b00068
Volume 17
Issue 6
Start page 1377
End page 1380
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2016
Language eng
Formatted abstract
Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi's universal NMR database.
Keyword Small molecule inhibitors
Structure elucidation
Absolute stereochemistry
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
 
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