Asymmetric total synthesis of (+)-dragmacidin D reveals unexpected stereocomplexity

Zhang, Fengying, Wang, Bin, Prasad, Pritesh, Capon, Robert J. and Jia, Yanxing (2015) Asymmetric total synthesis of (+)-dragmacidin D reveals unexpected stereocomplexity. Organic Letters, 17 6: 1529-1532. doi:10.1021/acs.orglett.5b00327


Author Zhang, Fengying
Wang, Bin
Prasad, Pritesh
Capon, Robert J.
Jia, Yanxing
Title Asymmetric total synthesis of (+)-dragmacidin D reveals unexpected stereocomplexity
Journal name Organic Letters   Check publisher's open access policy
ISSN 1523-7052
1523-7060
Publication date 2015-03-20
Sub-type Article (original research)
DOI 10.1021/acs.orglett.5b00327
Open Access Status
Volume 17
Issue 6
Start page 1529
End page 1532
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2016
Language eng
Abstract The first asymmetric total synthesis of the bis-indole marine alkaloid (+)-dragmacidin D (1) has been achieved. This synthesis revises an earlier configurational assignment based on biosynthetic considerations and assigns an R absolute configuration to (+)-1. The current studies reveal that natural dragmacidin D is isolated as either a racemate or a scalemic mixture (39% ee).
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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