How does B-value affect HARDI reconstruction using clinical diffusion MRI data?

Xie, Sangma, Zuo, Nianming, Shang, Liqing, Song, Ming, Fan, Lingzhong and Jiang, Tianzi (2015) How does B-value affect HARDI reconstruction using clinical diffusion MRI data?. PLoS One, 10 3: . doi:10.1371/journal.pone.0120773

Author Xie, Sangma
Zuo, Nianming
Shang, Liqing
Song, Ming
Fan, Lingzhong
Jiang, Tianzi
Title How does B-value affect HARDI reconstruction using clinical diffusion MRI data?
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-03-24
Year available 2015
Sub-type Article (original research)
DOI 10.1371/journal.pone.0120773
Open Access Status DOI
Volume 10
Issue 3
Total pages 19
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2015
Language eng
Formatted abstract
A number of imaging factors can affect the orientation distribution function (ODF) reconstruction in high angular resolution diffusion imaging (HARDI). The aim of this study was to investigate the effect of the b-value on the HARDI reconstruction and to seek for the appropriate b-value for ODF reconstruction from clinical HARDI data.

Diffusion MRI data with various b-values were collected on a GE 3T MRI scanner. To reconstruct the diffusion ODF and fiber ODF, decomposition-based spherical polar Fourier imaging and deconvolution-based constrained spherical deconvolution approaches were applied separately. The full width at half maximum (FWHM) of the ODF and the angular difference of the peaks extracted from ODF were measured to investigate the effect of b-value on the ODF reconstruction. Visual inspection of the ODF was used to evaluate the reconstructions.

The FWHM of the ODFs in the corpus callosum, which was chosen as the region of interest (ROI), decreased with increasing b-values. The differences in the FWHM for the diffusion ODF and the fiber ODF between the b-values of 2000 s/mm2 and 2500 s/mm2 were not significant. The angular differences of the ODF between 2000 s/mm2 and 2500 s/mm2 were lowest in both single-directional and two-directional situations. The ODFs became sharper and crossing-fiber situations were detected with an increase in b-value. B = 2000 s/mm2 and above revealed most of the two-way or three-way crossing-fiber structures.

Considering both the signal-to-noise ratio and the acquisition time, b = 2000 s/mm2 is the basic requirement for ODF reconstruction using current HARDI methods on clinical data. This study can provide a useful reference for researchers and clinicians attempting to set appropriate scan protocols for specific HARDI experiments
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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