Improving our resolution of kidney morphogenesis across time and space

Little, Melissa H (2015) Improving our resolution of kidney morphogenesis across time and space. Current Opinion in Genetics and Development, 32 135-143. doi:10.1016/j.gde.2015.03.001


Author Little, Melissa H
Title Improving our resolution of kidney morphogenesis across time and space
Journal name Current Opinion in Genetics and Development   Check publisher's open access policy
ISSN 1879-0380
0959-437X
Publication date 2015-06
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.gde.2015.03.001
Open Access Status
Volume 32
Start page 135
End page 143
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Elsevier Ltd
Collection year 2016
Language eng
Abstract As with many mammalian organs, size and cellular complexity represent considerable challenges to the comprehensive analysis of kidney organogenesis. Traditional analyses in the mouse have revealed early patterning events and spatial cellular relationships. However, an understanding of later events is lacking. The generation of a comprehensive temporospatial atlas of gene expression during kidney development has facilitated advances in lineage definition, as well as selective compartment ablation. Advances in quantitative and dynamic imaging have allowed comprehensive analyses at the level of organ, component tissue and cell across kidney organogenesis. Such approaches will enhance our understanding of the links between kidney development and final postnatal organ function. The final frontier will be translating this understanding to outcomes for renal disease in humans.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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