Long-Term Survival and Dialysis Dependency Following Acute Kidney Injury in Intensive Care: Extended Follow-up of a Randomized Controlled Trial

Gallagher M., Cass A., Bellomo R., Finfer S., Gattas D., Lee J., Lo S., McGuinness S., Myburgh J., Parke R., Rajbhandari D., Mitchell I., Taylor E., Whyte R., Raza A., Nand K., Sara T., Millis D., Wong H., Harrigan P., Hardie M., Whitaker D., Bhonagiri D., Micallef S., Ellem K., Lintott M., Cole L., Cuzner C., Weisbrodt L., Whereat S., Shehabi Y., Bass F., Edhouse P., Jenkins M., Finfer S., Bird S., O'Connor A., Totaro R., Honeysett L., Rajbhandari D., Myburgh J., Inskip D., Sidoli R., Nair P., Reynolds C., Banerjee A., Kong J., Skelly C., McGuinness S., Brown J., Gilder E., Parke R., McArthur C., Newby L., Simmonds C., Henderson S., Mehrtens J., Sugden D., Kalkoff M., McGregor K., Shaw C., Morgan J., Gregory K., Sutton J., Garrett P., Buckley A., McDonald S., Joyce C., Harward M., Sexton G., Perkins K., Lipman J., Dunlop R., Lassig-Smith M., Starr T., Flabouris A., O'Connor S., Rivett J., Turner A., McAllister R., Trubody V., Bellomo R., Eastwood G., Peck L., Fletcher J., Ihle B., Ho S., Micallef J., Murray L., Botha J., Allsop S., Vuat J., Cattigan C., Elderkin T., Walker C., Galt P., Gillies A., Harley N., Barge D., Caf T., Jordon A., Santamaria J., Holmes J., Smith R., Scheinkestel C., Donaldson H., Vallance S., French C., Bates S., Butler J., Breheny F., Palermo A., Dobb G., Chamberlain J., Lord P., Jun M., Yianni A. and D'Haeseleer S. (2014) Long-Term Survival and Dialysis Dependency Following Acute Kidney Injury in Intensive Care: Extended Follow-up of a Randomized Controlled Trial. PLoS Medicine, 11 2: 1-13. doi:10.1371/journal.pmed.1001601

Author Gallagher M.
Cass A.
Bellomo R.
Finfer S.
Gattas D.
Lee J.
Lo S.
McGuinness S.
Myburgh J.
Parke R.
Rajbhandari D.
Mitchell I.
Taylor E.
Whyte R.
Raza A.
Nand K.
Sara T.
Millis D.
Wong H.
Harrigan P.
Hardie M.
Whitaker D.
Bhonagiri D.
Micallef S.
Ellem K.
Lintott M.
Cole L.
Cuzner C.
Weisbrodt L.
Whereat S.
Shehabi Y.
Bass F.
Edhouse P.
Jenkins M.
Finfer S.
Bird S.
O'Connor A.
Totaro R.
Honeysett L.
Rajbhandari D.
Myburgh J.
Inskip D.
Sidoli R.
Nair P.
Reynolds C.
Banerjee A.
Kong J.
Skelly C.
McGuinness S.
Brown J.
Gilder E.
Parke R.
McArthur C.
Newby L.
Simmonds C.
Henderson S.
Mehrtens J.
Sugden D.
Kalkoff M.
McGregor K.
Shaw C.
Morgan J.
Gregory K.
Sutton J.
Garrett P.
Buckley A.
McDonald S.
Joyce C.
Harward M.
Sexton G.
Perkins K.
Lipman J.
Dunlop R.
Lassig-Smith M.
Starr T.
Flabouris A.
O'Connor S.
Rivett J.
Turner A.
McAllister R.
Trubody V.
Bellomo R.
Eastwood G.
Peck L.
Fletcher J.
Ihle B.
Ho S.
Micallef J.
Murray L.
Botha J.
Allsop S.
Vuat J.
Cattigan C.
Elderkin T.
Walker C.
Galt P.
Gillies A.
Harley N.
Barge D.
Caf T.
Jordon A.
Santamaria J.
Holmes J.
Smith R.
Scheinkestel C.
Donaldson H.
Vallance S.
French C.
Bates S.
Butler J.
Breheny F.
Palermo A.
Dobb G.
Chamberlain J.
Lord P.
Jun M.
Yianni A.
D'Haeseleer S.
Title Long-Term Survival and Dialysis Dependency Following Acute Kidney Injury in Intensive Care: Extended Follow-up of a Randomized Controlled Trial
Journal name PLoS Medicine   Check publisher's open access policy
ISSN 1549-1676
Publication date 2014
Sub-type Article (original research)
DOI 10.1371/journal.pmed.1001601
Open Access Status DOI
Volume 11
Issue 2
Start page 1
End page 13
Total pages 13
Place of publication San Francisco, CA, U.S.A.
Publisher Public Library of Science
Collection year 2015
Language eng
Subject 2700 Medicine
Abstract Background:The incidence of acute kidney injury (AKI) is increasing globally and it is much more common than end-stage kidney disease. AKI is associated with high mortality and cost of hospitalisation. Studies of treatments to reduce this high mortality have used differing renal replacement therapy (RRT) modalities and have not shown improvement in the short term. The reported long-term outcomes of AKI are variable and the effect of differing RRT modalities upon them is not clear. We used the prolonged follow-up of a large clinical trial to prospectively examine the long-term outcomes and effect of RRT dosing in patients with AKI.Methods and Findings:We extended the follow-up of participants in the Randomised Evaluation of Normal vs. Augmented Levels of RRT (RENAL) study from 90 days to 4 years after randomization. Primary and secondary outcomes were mortality and requirement for maintenance dialysis, respectively, assessed in 1,464 (97%) patients at a median of 43.9 months (interquartile range [IQR] 30.0-48.6 months) post randomization. A total of 468/743 (63%) and 444/721 (62%) patients died in the lower and higher intensity groups, respectively (risk ratio [RR] 1.04, 95% CI 0.96-1.12, p = 0.49). Amongst survivors to day 90, 21 of 411 (5.1%) and 23 of 399 (5.8%) in the respective groups were treated with maintenance dialysis (RR 1.12, 95% CI 0.63-2.00, p = 0.69). The prevalence of albuminuria among survivors was 40% and 44%, respectively (p = 0.48). Quality of life was not different between the two treatment groups. The generalizability of these findings to other populations with AKI requires further exploration.Conclusions:Patients with AKI requiring RRT in intensive care have high long-term mortality but few require maintenance dialysis. Long-term survivors have a heavy burden of proteinuria. Increased intensity of RRT does not reduce mortality or subsequent treatment with dialysis.Trial registration:http://www.ClinicalTrials.gov NCT00221013 Please see later in the article for the Editors' Summary.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
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Created: Wed, 01 Apr 2015, 21:21:06 EST by Matthew Lamb on behalf of School of Medicine