Differential requirement for Nfil3 during NK cell development

Seillet C., Huntington N.D., Gangatirkar P., Axelsson E., Minnich M., Brady H.J.M., Busslinger M., Smyth M.J., Belz G.T. and Carotta S. (2014) Differential requirement for Nfil3 during NK cell development. Journal of Immunology, 192 6: 2667-2676. doi:10.4049/jimmunol.1302605


Author Seillet C.
Huntington N.D.
Gangatirkar P.
Axelsson E.
Minnich M.
Brady H.J.M.
Busslinger M.
Smyth M.J.
Belz G.T.
Carotta S.
Title Differential requirement for Nfil3 during NK cell development
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 1550-6606
0022-1767
Publication date 2014-03-15
Sub-type Article (original research)
DOI 10.4049/jimmunol.1302605
Open Access Status DOI
Volume 192
Issue 6
Start page 2667
End page 2676
Total pages 10
Place of publication Bethesda, MD, U.S.A.
Publisher American Association of Immunologists
Collection year 2015
Language eng
Subject 2403 Immunology
Abstract NK cells can be grouped into distinct subsets that are localized to different organs and exhibit a different capacity to secrete cytokines and mediate cytotoxicity. Despite these hallmarks that reflect tissue-specific specialization in NK cells, little is known about the factors that control the development of these distinct subsets. The basic leucine zipper transcription factor Nfil3 (E4bp4) is essential for bone marrow-derived NK cell development, but it is not clear whether Nfil3 is equally important for all NK cell subsets or how it induces NK lineage commitment. In this article, we show that Nfil3 is required for the formation of Eomes-expressing NK cells, including conventional medullary and thymic NK cells, whereas TRAIL+ Eomes- NK cells develop independently of Nfil3. Loss of Nfil3 during the development of bone marrow-derived NK cells resulted in reduced expression of Eomes and, conversely, restoration of Eomes expression in Nfil3-/- progenitors rescued NK cell development and maturation. Collectively, these findings demonstrate that Nfil3 drives the formation of mature NK cells by inducing Eomes expression and reveal the differential requirements of NK cell subsets for Nfil3. The Journal of Immunology, 2014, 192: 2667-2676.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 31 Mar 2015, 22:40:40 EST by Matthew Lamb on behalf of School of Medicine