Effect of acarbose on postprandial blood glucose concentrations in healthy cats fed low and high carbohydrate diets

Singh, Ranee, Rand, Jacquie S., Coradini, Marcia and Morton, John M. (2014) Effect of acarbose on postprandial blood glucose concentrations in healthy cats fed low and high carbohydrate diets. Journal of Feline Medicine and Surgery, 1-10. doi:10.1177/1098612X14556559


Author Singh, Ranee
Rand, Jacquie S.
Coradini, Marcia
Morton, John M.
Title Effect of acarbose on postprandial blood glucose concentrations in healthy cats fed low and high carbohydrate diets
Journal name Journal of Feline Medicine and Surgery   Check publisher's open access policy
ISSN 1098-612X
1532-2750
Publication date 2014-10-24
Year available 2014
Sub-type Article (original research)
DOI 10.1177/1098612X14556559
Open Access Status
Start page 1
End page 10
Total pages 10
Place of publication Manila, Philippines
Publisher World Health Organization * Regional Office for the Western Pacific
Collection year 2015
Language eng
Formatted abstract
Objectives Feeding a low carbohydrate diet is recommended for diabetic cats; however, some cats may require diets containing moderate-to-high carbohydrate and may benefit from the use of therapeutic agents to improve glycemic control. The aim of the study was to determine the effect of the α-glucosidase inhibitor acarbose on postprandial plasma glucose concentration when combined with commercially available feline diets high and low in carbohydrate.

Methods Twelve healthy, adult, non-obese, neutered cats were enrolled. Plasma glucose concentrations were assessed over 24 h after feeding high and low carbohydrate diets, with and without acarbose, during single and multiple meal tests, in a crossover study. Commercially available feline diets were used, which were high and low in carbohydrate (providing 51% and 7% of metabolizable energy, respectively).

Results In cats fed the high carbohydrate diet as a single meal, mean 24 h glucose concentrations were lower when acarbose was administered. Mean glucose concentrations were lower in the first 12 h when acarbose was given once daily, whereas no significant difference was observed in mean results from 12–24 h. Acarbose had little effect in cats eating multiple meals. Compared with consumption of the high carbohydrate diet with acarbose, lower mean 24 h and peak glucose concentrations were achieved by feeding the low carbohydrate diet alone.

Conclusions and relevance In healthy cats meal-fed diets of similar composition to the diets used in this study, acarbose has minimal effect when a low carbohydrate diet is fed but reduces postprandial glucose concentrations over 24 h when a high carbohydrate diet is fed. However, mean glucose concentrations over 24 h are still higher when a high carbohydrate diet with acarbose is fed relative to the low carbohydrate diet without acarbose. Future studies in diabetic cats are warranted to confirm these findings.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print Oct 24 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Veterinary Science Publications
 
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Created: Tue, 31 Mar 2015, 12:26:40 EST by Professor Jacquie Rand on behalf of School of Veterinary Science