TGF-beta1 interactome: metastasis and beyond

Perera, M., Tsang, C. S., Distel, R. J., Lacy, J. N., Ohno-Machado, L., Ricchiuti, V., Samaranayake, L. P., Smejkal, G. B., Smith, M. G., Trachtenberg, A. J. and Kuo, W. P. (2010) TGF-beta1 interactome: metastasis and beyond. Cancer Genomics & Proteomics, 7 4: 217-229.

Author Perera, M.
Tsang, C. S.
Distel, R. J.
Lacy, J. N.
Ohno-Machado, L.
Ricchiuti, V.
Samaranayake, L. P.
Smejkal, G. B.
Smith, M. G.
Trachtenberg, A. J.
Kuo, W. P.
Title TGF-beta1 interactome: metastasis and beyond
Formatted title
TGF-β1 interactome: metastasis and beyond
Journal name Cancer Genomics & Proteomics   Check publisher's open access policy
ISBN 1109-6535
Publication date 2010-07
Sub-type Article (original research)
Open Access Status
Volume 7
Issue 4
Start page 217
End page 229
Total pages 13
Place of publication Kapandriti Attica, Attiki, Greece
Publisher International Institute of Anticancer Research
Language eng
Formatted abstract
The ubiquitous cytokine transforming growth factor-β1 (TGF-β1) is one of the most potent metastatic inducers. Functional interactomic mapping using high-throughput proteomic and genomic data provides valuable insights into the regulation of tumor suppressive and metastatic attributes of TGF-β1. Polarity changes of the TGF-β1 interactome at a given time contributes to these contrasting effects. Differential expression profiles of pivotal interactomic nodes contribute to these polarity changes. These insights are of immense value in the development of effective cancer therapeutics. Moreover, TGF-β1 interactomic nodes are useful in discovering novel cancer biomarkers. This review describes an initial version of the TGF-β1 interactome in relation to tumor progression and metastasis. Thus, this review embodies an important step towards the mapping of comprehensive and individualized TGF-β1 interactomes that will assist in the development of personalized cancer therapeutics.
Keyword Transforming growth factor-β1
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
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Created: Tue, 31 Mar 2015, 11:09:47 EST by Margot Dallinger on behalf of School of Dentistry