HLA class I associations with EBV+ post-transplant lymphoproliferative disorder

Jones, Kimberley, Wockner, Leesa, Thornton, Alycia, Gottlieb, David, Ritchie, David S, Seymour, John F, Kumarasinghe, Gayathri and Gandhi, Maher K (2015) HLA class I associations with EBV+ post-transplant lymphoproliferative disorder. Transplant Immunology, 32 2: 126-130. doi:10.1016/j.trim.2015.02.005

Author Jones, Kimberley
Wockner, Leesa
Thornton, Alycia
Gottlieb, David
Ritchie, David S
Seymour, John F
Kumarasinghe, Gayathri
Gandhi, Maher K
Title HLA class I associations with EBV+ post-transplant lymphoproliferative disorder
Journal name Transplant Immunology   Check publisher's open access policy
ISSN 1878-5492
Publication date 2015-03
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.trim.2015.02.005
Volume 32
Issue 2
Start page 126
End page 130
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Epstein–Barr virus (EBV) is frequently associated with post-transplant lymphoproliferative disorders (EBV+ PTLD). In these cases, impaired Epstein–Barr virus (EBV)-specific CD8+ T-cell immunity is strongly implicated and antigen presentation within the malignant B-cell is intact. Interestingly, several studies have reported HLA class I alleles with protective or susceptibility associations. However, results are conflicting, likely influenced by methodology including inconsistent use of multiple hypothesis testing. By contrast, HLA class I associations have been repeatedly reported for classical Hodgkin Lymphoma (cHL), in which EBV is also implicated in a proportion of cases. In contrast to EBV+ PTLD which expresses the immunodominant EBV latency III EBNA3A/B/C proteins, EBV+ cHL is restricted to the subdominant EBNA1/LMP1/LMP2 proteins. Herein, we report a study of HLA class I associations in EBV+ PTLD, with 263 patients with lymphoma (cHL or PTLD) evaluated. Two Australian population cohorts, n = 23,736 and n = 891 were used for comparison. Contrary to previous reports, no HLA class I associations with EBV+ PTLD were found, whereas for cHL known HLA class I associations were confirmed, with HLA-A*02 homozygous individuals having the lowest odds of developing EBV+ cHL. Our results suggest that HLA class I does not influence susceptibility to the viral latency III expressing lymphoma, EBV+ PTLD. Further studies are required for definitive confirmation.
Keyword Epstein-Barr virus
Post-transplant lymphoproliferative disorder
HLA class I
Genetic association
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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