Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

Eslam, Mohammed, Hashem, Ahmed M, Leung, Reynold, Romero-Gomez, Manuel, Berg, Thomas, Dore, Gregory J, Chan, Henry L.K, Irving, William L, Sheridan, David, Abate, Maria L, Adams, Leon A, Mangia, Alessandra, Weltman, Martin, Bugianesi, Elisabetta, Spengler, Ulrich, Shaker, Olfat, Fischer, Janett, Mollison, Lindsay, Cheng, Wendy, Powell, Elizabeth, Nattermann, Jacob, Riordan, Stephen, McLeod, Duncan, Armstrong, Nicola J, Douglas, Mark W, Liddle, Christopher, Booth, David R, George, Jacob, Ahlenstiel, Golo, Ampuero, Javier, Bassendine, Margaret, Wong, Vincent W.S, Rosso, Chiara, White, Rose, Mezzabotta, Lavinia, Suppiah, Vijayaprakash, Michalk, Monika, Malik, Barbara, Matthews, Gail, Applegate, Tanya, Grebely, Jason, Fragomeli, Vincenzo, Jonsson, Julie R and Santaro, Rosanna (2015) Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. Nature Communications, 6 6422: . doi:10.1038/ncomms7422


Author Eslam, Mohammed
Hashem, Ahmed M
Leung, Reynold
Romero-Gomez, Manuel
Berg, Thomas
Dore, Gregory J
Chan, Henry L.K
Irving, William L
Sheridan, David
Abate, Maria L
Adams, Leon A
Mangia, Alessandra
Weltman, Martin
Bugianesi, Elisabetta
Spengler, Ulrich
Shaker, Olfat
Fischer, Janett
Mollison, Lindsay
Cheng, Wendy
Powell, Elizabeth
Nattermann, Jacob
Riordan, Stephen
McLeod, Duncan
Armstrong, Nicola J
Douglas, Mark W
Liddle, Christopher
Booth, David R
George, Jacob
Ahlenstiel, Golo
Ampuero, Javier
Bassendine, Margaret
Wong, Vincent W.S
Rosso, Chiara
White, Rose
Mezzabotta, Lavinia
Suppiah, Vijayaprakash
Michalk, Monika
Malik, Barbara
Matthews, Gail
Applegate, Tanya
Grebely, Jason
Fragomeli, Vincenzo
Jonsson, Julie R
Santaro, Rosanna
Title Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2015-03-05
Year available 2015
Sub-type Article (original research)
DOI 10.1038/ncomms7422
Open Access Status DOI
Volume 6
Issue 6422
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Abstract Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of ​interferon-λ4 (​IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for all). The impact of rs12979860 genotypes on fibrosis is maximal in young females, especially those with HCV genotype 3. These findings establish rs12979860 genotype as a strong aetiology-independent predictor of tissue inflammation and fibrosis.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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