Development of an EORTC-8D utility algorithm for Sri Lanka

Kularatna, Sanjeewa, Whitty, Jennifer A., Johnson, Newell W., Jayasinghe, Ruwan and Scuffham, Paul A. (2015) Development of an EORTC-8D utility algorithm for Sri Lanka. Medical Decision Making, 35 3: 361-370. doi:10.1177/0272989X14559274


Author Kularatna, Sanjeewa
Whitty, Jennifer A.
Johnson, Newell W.
Jayasinghe, Ruwan
Scuffham, Paul A.
Title Development of an EORTC-8D utility algorithm for Sri Lanka
Journal name Medical Decision Making   Check publisher's open access policy
ISSN 1552-681X
0272-989X
Publication date 2015-04-20
Year available 2014
Sub-type Article (original research)
DOI 10.1177/0272989X14559274
Open Access Status
Volume 35
Issue 3
Start page 361
End page 370
Total pages 10
Place of publication Thousand Oaks CA, United States
Publisher Sage Publications
Collection year 2015
Language eng
Formatted abstract
Background. Currently there are no reported cancer-specific health state valuations in low- and middle-income countries using a validated preference-based measure. The EORTC-8D, a cancer-specific preference-based measure, has 81,920 health states and is useful for economic evaluations in cancer care. The aim of this study was to develop a utility algorithm to value EORTC-8D health states using preferences derived from a representative population sample in Sri Lanka. Methods. The time-tradeoff method was used to elicit preferences from a general population sample of 780 in Sri Lanka. A block design of 85 health states, with a time horizon of 10 years, was used for the direct valuation. Data were analyzed using generalized least squares with random effects. All respondents with at least one logical inconsistency were excluded from the analysis. Results. After logical inconsistencies were excluded, 4520 observations were available from 717 respondents for the analysis. The preferred model specified main effects with an interaction term for any level 4 or worse descriptor within a health state. Worsening of physical functioning had a substantially greater utility decrement than any other dimension in this population. Limitations are that the data collection could not include the whole country and that females formed a large part of the sample. Conclusions. Preference weights for EORTC-8D health states for Sri Lanka have been derived: These will be very useful in economic evaluations of cancer-related interventions in a range of low- and middle-income countries.
Keyword EORTC-8D
Utility
Health state valuation
TTO
Sri Lanka
QALY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 17 Nov 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Pharmacy Publications
 
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