Pharmacokinetics of intravenous, plain oral and enteric-coated oral omeprazole in the horse

Sykes, B. W., Underwood, C., Mcgowan, C. M. and Mills, P. C. (2015) Pharmacokinetics of intravenous, plain oral and enteric-coated oral omeprazole in the horse. Journal of Veterinary Pharmacology and Therapeutics, 38 2: 130-136. doi:10.1111/jvp.12169


Author Sykes, B. W.
Underwood, C.
Mcgowan, C. M.
Mills, P. C.
Title Pharmacokinetics of intravenous, plain oral and enteric-coated oral omeprazole in the horse
Journal name Journal of Veterinary Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0140-7783
1365-2885
Publication date 2015-04-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/jvp.12169
Volume 38
Issue 2
Start page 130
End page 136
Total pages 7
Place of publication Chichester, West Sussex, United Kingdom
Publisher Blackwell Publishing
Collection year 2015
Language eng
Formatted abstract
The objectives were to document the pharmacokinetics of intravenous, enteric-coated oral and plain oral omeprazole in fasted horses and to investigate the impact of feeding on the bioavailability of an enteric-coated omeprazole. Twelve horses received four treatments: intravenous omeprazole (0.5 mg/kg) in the fasted state (IV-Fasted), enteric-coated omeprazole (4 mg/kg) orally in the fasted state (ECO-Fasted), enteric-coated omeprazole (4 mg/kg) orally in the fed state (ECO-Fed) and plain omeprazole (4 mg/kg) orally in the fasted state (PL-Fasted). Plasma omeprazole concentrations were determined by UHPLC-MS. Bioavailability was higher (P = 0.038) in the ECO-Fasted group (21.5 [9.0–27.7]%) than the PL-Fasted group (10.1 [7.7–13.3]%). Similarly, AUC0-∞ was higher in the ECO-Fasted group than the PL-Fasted group (P = 0.027). No significant differences were present between the ECO-Fasted and ECO-Fed groups with regards to bioavailability, Cmax, Tmax or AUC0-∞. When the half-life data from the oral formulations was pooled, it was longer than that observed in the IV-Fasted group (100 [73–118] min) and 35 [34-39] min, respectively; P < 0.0001). Bioavailability of enteric-coated omeprazole was higher than previously reported and feeding had minimal impact. Bioavailability of plain omeprazole was approximately half that of enteric-coated omeprazole. The longer half-life observed following oral administration was consistent with the flip-flop effect and has not previously been described for omeprazole in the horse.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Veterinary Science Publications
 
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