Specific IgE recognition of pollen allergens from subtropic grasses in patients from the subtropics

Nony, Emmanuel, Timbrell, Victoria, Hrabina, Maud, Boutron, Melanie, Solley, Graham, Moingeon, Philippe and Davies, Janet M (2015) Specific IgE recognition of pollen allergens from subtropic grasses in patients from the subtropics. Annals of Allergy, Asthma and Immunology, 114 3: 214-220.e2. doi:10.1016/j.anai.2014.12.005

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Author Nony, Emmanuel
Timbrell, Victoria
Hrabina, Maud
Boutron, Melanie
Solley, Graham
Moingeon, Philippe
Davies, Janet M
Title Specific IgE recognition of pollen allergens from subtropic grasses in patients from the subtropics
Journal name Annals of Allergy, Asthma and Immunology   Check publisher's open access policy
ISSN 1534-4436
Publication date 2015-03-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.anai.2014.12.005
Volume 114
Issue 3
Start page 214
End page 220.e2
Total pages 9
Place of publication New York, United States
Publisher Elsevier Inc
Collection year 2016
Language eng
Formatted abstract

Pollens of subtropical grasses, Bahia ( Paspalum notatum ), Johnson ( Sorghum halepense ), and Bermuda ( Cynodon dactylon ), are common causes of respiratory allergies in subtropical regions worldwide.


To evaluate IgE cross-reactivity of grass pollen (GP) found in subtropical and temperate areas.


Case and control serum samples from 83 individuals from the subtropical region of Queensland were tested for IgE reactivity with GP extracts by enzyme-linked immunosorbent assay. A randomly sampled subset of 21 serum samples from patients with subtropical GP allergy were examined by ImmunoCAP and cross-inhibition assays.


Fifty-four patients with allergic rhinitis and GP allergy had higher IgE reactivity with P notatum and C dactylon than with a mixture of 5 temperate GPs. For 90% of 21 GP allergic serum samples, P notatum , S halepense , or C dactylon specific IgE concentrations were higher than temperate GP specific IgE, and GP specific IgE had higher correlations of subtropical GP ( r = 0.771–0.950) than temperate GP ( r = 0.317–0.677). In most patients (71%-100%), IgE with P notatum , S halepense, or C dactylon GPs was inhibited better by subtropical GP than temperate GP. When the temperate GP mixture achieved 50% inhibition of IgE with subtropical GP, there was a 39- to 67-fold difference in concentrations giving 50% inhibition and significant differences in maximum inhibition for S halepense and P notatum GP relative to temperate GP.


Patients living in a subtropical region had species specific IgE recognition of subtropical GP. Most GP allergic patients in Queensland would benefit from allergen specific immunotherapy with a standardized content of subtropical GP allergens.
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Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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