Droperidol v. haloperidol for sedation of aggressive behaviour in acute mental health: Randomized controlled trial

Calver, Leonie, Drinkwater, Vincent, Gupta, Rahul, Page, Colin B and Isbister, Geoffrey K (2015) Droperidol v. haloperidol for sedation of aggressive behaviour in acute mental health: Randomized controlled trial. British Journal of Psychiatry, 206 3: 223-228. doi:10.1192/bjp.bp.114.150227


Author Calver, Leonie
Drinkwater, Vincent
Gupta, Rahul
Page, Colin B
Isbister, Geoffrey K
Title Droperidol v. haloperidol for sedation of aggressive behaviour in acute mental health: Randomized controlled trial
Journal name British Journal of Psychiatry   Check publisher's open access policy
ISSN 1472-1465
0007-1250
Publication date 2015-03
Year available 2015
Sub-type Article (original research)
DOI 10.1192/bjp.bp.114.150227
Volume 206
Issue 3
Start page 223
End page 228
Total pages 7
Place of publication London, United Kingdom
Publisher Royal College of Psychiatrists
Collection year 2016
Language eng
Formatted abstract
Background

Agitation and aggression are significant problems in acute psychiatric units. There is little consensus on which drug is most effective and safest for sedation of these patients.

Aims


To compare the effectiveness and safety of haloperidol v. droperidol for patients with agitation and aggression.

Method


In a masked, randomised controlled trial (ACTRN12611000565943) intramuscular droperidol (10 mg) was compared with intramuscular haloperidol (10 mg) for adult patients with acute behavioural disturbance in a psychiatric intensive care unit. The primary outcome was time to sedation within 120 min. Secondary outcomes were use of additional sedation, adverse events and staff injuries.

Results

From 584 patients, 110 were randomised to haloperidol and 118 to droperidol. Effective sedation occurred in 210 (92%) patients within 120 min. There was no significant difference in median time to sedation: 20 min (interquartile range 15–30, range 10–75) for haloperidol v. 25 min (IQR 15–30, range 10–115) for droperidol (P = 0.89). Additional sedation was used more often with haloperidol (13% v. 5%, P = 0.06), but adverse effects were less common with haloperidol (1% v. 5%, P = 0.12). There were 8 staff injuries.

Conclusions


Both haloperidol and droperidol were effective for sedation of patients with acute behavioural disturbance.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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