Solar elastosis and cutaneous melanoma: a site-specific analysis

Kvaskoff, Marina, Pandeya, Nirmala, Green, Adèle C., Perry, Susan, Baxter, Catherine, Davis, Marcia B., Mortimore, Rohan, Westacott, Lorraine, Wood, Dominic, Triscott, Joe, Williamson, Richard and Whiteman, David C. (2014) Solar elastosis and cutaneous melanoma: a site-specific analysis. International Journal of Cancer, 136 12: 2900-2911. doi:10.1002/ijc.29335


Author Kvaskoff, Marina
Pandeya, Nirmala
Green, Adèle C.
Perry, Susan
Baxter, Catherine
Davis, Marcia B.
Mortimore, Rohan
Westacott, Lorraine
Wood, Dominic
Triscott, Joe
Williamson, Richard
Whiteman, David C.
Title Solar elastosis and cutaneous melanoma: a site-specific analysis
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 1097-0215
0020-7136
Publication date 2014-11-26
Year available 2014
Sub-type Article (original research)
DOI 10.1002/ijc.29335
Open Access Status
Volume 136
Issue 12
Start page 2900
End page 2911
Total pages 12
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2015
Language eng
Formatted abstract
Cutaneous melanomas are postulated to arise through at least two causal pathways, namely the “chronic sun exposure” and “nevus” pathways. While chronic sun exposure probably causes many head/neck melanomas, its role at other sites is unclear. In a population-based, case-case comparison study conducted in Brisbane, Australia, we determined the prevalence and epidemiologic correlates of chronic solar damage in skin adjacent to invasive, incident melanomas on the trunk (n = 418) or head/neck (n = 92) among patients aged 18–79 in 2007–2010. Participants self-reported information about environmental and phenotypic factors, and a dermatologist counted nevi and actinic keratoses. Dermatopathologists assessed solar elastosis adjacent to each melanoma using a four-point scale (nil, mild, moderate, marked), and noted the presence or absence of adjacent neval remnants. We measured associations between various factors and solar elastosis using polytomous logistic regression. Marked or moderate solar elastosis was observed in 10% and 27%, respectively, of trunk melanomas, and 60% and 17%, respectively, of head/neck melanomas. At both sites, marked elastosis was positively associated with age (ptrend < 0.0001) and inversely associated with neval remnants (ptrend < 0.001). For trunk melanomas, marked elastosis was associated with highest quartiles of total sun exposure [odds-ratio (OR) = 5.47, 95% confidence interval (CI) = 1.08–27.60] and facial freckling (OR = 2.98, 95% CI = 1.17–7.56), and inversely associated with deeply tanning skin (OR = 0.29, 95% CI = 0.08–1.11) and high nevus counts (OR = 0.08, 95% CI = 0.01–0.66). Mostly similar associations were observed with moderate solar elastosis. About one in three trunk melanomas in Queensland have evidence of moderate-to-marked sun damage, and they differ in risk associations from those without.
Keyword Cutaneous melanoma
Solar elastosis
Epidemiology
Melanocytic nevus
Actinic keratoses
Sun exposure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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Created: Mon, 30 Mar 2015, 11:26:54 EST by Mrs Nirmala Pandeya on behalf of School of Public Health