Altered cortical thickness following prenatal sodium valproate exposure.

Wood, Amanda G., Chen, Jian, Barton, Sarah, Nadebaum, Caroline, Anderson, Vicki A., Catroppa, Cathy, Reutens, David C., O'Brien, Terence J. and Vajda, Frank (2014) Altered cortical thickness following prenatal sodium valproate exposure.. Annals of Clinical and Translational Neurology, 1 7: 497-501. doi:10.1002/acn3.74

Author Wood, Amanda G.
Chen, Jian
Barton, Sarah
Nadebaum, Caroline
Anderson, Vicki A.
Catroppa, Cathy
Reutens, David C.
O'Brien, Terence J.
Vajda, Frank
Title Altered cortical thickness following prenatal sodium valproate exposure.
Journal name Annals of Clinical and Translational Neurology   Check publisher's open access policy
ISSN 2328-9503
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1002/acn3.74
Open Access Status DOI
Volume 1
Issue 7
Start page 497
End page 501
Total pages 5
Place of publication West Sussex, United Kingdom
Publisher John Wiley and Sons
Collection year 2015
Language eng
Formatted abstract
Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Created: Mon, 30 Mar 2015, 08:42:11 EST by David Reutens on behalf of Queensland Brain Institute