Impact of experimental hookworm infection on the human gut microbiota

Cantacessi, Cinzia, Giacomin, Paul, Croese, John, Zakrzewski, Martha, Sotillo, Javier, McCann, Leisa, Nolan, Matthew J., Mitreva, Makedonka, Krause, Lutz and Loukas, Alex (2014) Impact of experimental hookworm infection on the human gut microbiota. The Journal of Infectious Diseases, 210 9: 1431-1434. doi:10.1093/infdis/jiu256

Author Cantacessi, Cinzia
Giacomin, Paul
Croese, John
Zakrzewski, Martha
Sotillo, Javier
McCann, Leisa
Nolan, Matthew J.
Mitreva, Makedonka
Krause, Lutz
Loukas, Alex
Title Impact of experimental hookworm infection on the human gut microbiota
Journal name The Journal of Infectious Diseases   Check publisher's open access policy
ISSN 1537-6613
Publication date 2014-11-01
Year available 2014
Sub-type Article (original research)
DOI 10.1093/infdis/jiu256
Open Access Status
Volume 210
Issue 9
Start page 1431
End page 1434
Total pages 4
Place of publication Cary, NC United States
Publisher Oxford University Press
Collection year 2015
Language eng
Formatted abstract
The interactions between gastrointestinal parasitic helminths and commensal bacteria are likely to play a pivotal role in the establishment of host-parasite cross-talk, ultimately shaping the development of the intestinal immune system. However, little information is available on the impact of infections by gastrointestinal helminths on the bacterial communities inhabiting the human gut. We used 16S rRNA gene amplification and pyrosequencing to characterize, for the first time to our knowledge, the differences in composition and relative abundance of fecal microbial communities in human subjects prior to and following experimental infection with the blood-feeding intestinal hookworm, Necator americanus. Our data show that, although hookworm infection leads to a minor increase in microbial species richness, no detectable effect is observed on community structure, diversity or relative abundance of individual bacterial species.
Keyword Experimental infection
Parasitic helminths
16S rRNA gene
Chronic inflammatory disorders
Microbial richness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
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Created: Fri, 27 Mar 2015, 15:47:24 EST by Kylie Hengst on behalf of UQ Diamantina Institute